Axle Informatics

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Job Locations US
Axle Informatics is a bioinformatics and information technology company that offers innovative computer services, informatics, and enterprise solutions to research centers and healthcare organizations around the globe. With experts in software engineering, bioinformatics and program management, we focus on developing and applying technology tools and techniques to empower decision-making and accelerate the discovery in translational research. We work with some of the top research organizations and facilities in the country including multiple institutes at the National Institutes of health (NIH).   Axle is seeking a highly ambitious, adaptable, structured, and detail oriented Research Associate to join our rare disease informatics team at Bethesda, MD.    Currently, there are about 7,000-10,000 known rare diseases that affect people in the US, yet only a few hundred (less than 5%) have a treatment and even fewer a cure.  A rare disease is defined in US law (Orphan Drug Act (ODA) of 1983,[1] Rare Diseases Act (RDA) of 2002[2]) as a disease or condition that affects fewer than 200,000 people in the US. Most rare diseases affect far fewer patients than this, with most rare diseases affecting only a few hundreds to thousands of patients. Collectively, however, rare diseases are not rare at all, and in total are estimated to affect as many as 25-30 million patients in the US, making rare diseases a large public health consideration.    The ORDR’s GARD information center was established in 2003 under a Congressional Mandate (RDA 2002), and is a federally funded program that has an essential role in the dissemination of public health information to rare disease researchers, clinicians, and patients that is freely accessible to the public.  However, obtaining accurate, comprehensive, timely, and objective information on rare diseases is often difficult, given the large number of rare diseases, rapidly evolving science (especially related to genomics), diverse data sources, and inconsistent nomenclature and ontologies for rare disease classification, among other issues. Recently, GARD has been undergoing a re-envisioning and re-design based on a Neo4j knowledge graph database that integrates rare disease data from multiple sources to keep the information on ~6,000 different rare diseases in GARD up-to-date and useful to the patient and clinical research communities. Research tools, artificial intelligent models, data visualization and informatics infrastructure based on the knowledge graph database will be developed to support rare diseases research and clinical activities, and to answer rare disease research questions likely to inform rare disease research prioritization.    [1] Orphan Drug Act of 1983, amended for prevalence 1984. Pub.L. 97-414 [2] Rare Diseases Act of 2002, Pub.L. 107-280
ID
2023-3796
Job Locations US-MD-Bethesda
Axle Informatics is a bioscience and information technology company that offers advancements in translational research, biomedical informatics, and data science applications to research centers and healthcare organizations around the globe. With experts in biomedical science, software engineering, and program management, we focus on developing and applying research tools and techniques to empower decision-making and accelerate research discoveries. We work with some of the top research organizations and facilities in the country including multiple institutes at the National Institutes of Health (NIH).   Overview Axle is seeking a highly ambitious, adaptable, structured, and detail-oriented Medical Officer  to join our vibrant team at the National Institutes of Health (NIH), National Institute of Allergy and Infectious Diseases (NIAID, Division AIDS (DAIDS), Translational Research Program (TRP),TB Clinical Research Branch (TCRB)   Responsibilities - Participate in the review, planning and implementation of clinical trials for the treatment and/or prevention of HIV/AIDS, it co-infections and/or related co-morbidities. This includes evaluating the hypothesis, objectives, study design, feasibility, and regulatory requirements, as well as identifying medical and logistical problems that may impede a study. - Advise program management of merits and deficiencies in proposed clinical studies - Provide subject matter expertise during protocol development leading to review at the Division level and ensures that the concerns raised during the review are addressed by the Protocol Development Team in a timely manner. - Provide clinical expertise to assist in developing Investigational New Drug (IND) applications. Individuals providing this expertise will be named as reviewer of information relevant to the safety of the drug in question, on line 15 and 16 of the IND application (FDA Form 1571). - Evaluate annual IND annual reports for medical safety and report findings to RAB. •Provide medical expertise in protocol follow-up stages for subject safety and protection, reliability of study endpoint data and makes appropriate recommendations to DAIDS’ leadership to ensure trials are conducted according to protocol. - Provide clinical and scientific information for preparing NIAID communications to the Food and Drug Administration (FDA), other government and nongovernmental agencies, pharmaceutical companies and Data Safety Monitoring Boards - Conducts site visits, when necessary, to obtain additional data and information for use by federal staff, in the consideration and evaluation of ongoing and future programs. - Preview serious adverse event (SAE) reports, provides expert medical advice for potential impact of SAEs in ongoing research and participates in the preparation of reports submitted to the FDA.   Experience Required / Requirements - MD degree in a related field. - Minimum of 20+ years’ experience in clinical trials research.   Benefits - 100% Medical, Dental & Vision premium coverage for Employees - Paid Time Off (Including Holidays) - Employee Referral Bonus - 401K Match - Tuition reimbursement and professional development opportunities - Flexible Spending Accounts: - Healthcare (FSA) - Parking Reimbursement Account (PRK) - Dependent Care Assistant Program (DCAP) - Transportation Reimbursement Account (TRN)   The diversity of Axle’s employees is a tremendous asset. We are firmly committed to providing equal opportunity in all aspects of employment and will not tolerate any illegal discrimination or harassment-based age, race, gender, religion, national origin, disability, marital status, covered veteran status, sexual orientation, status with respect to public assistance, and other characteristics protected under state, federal, or local law and to deter those who aid, abet, or induce discrimination or coerce others to discriminate.   Accessibility: If you need an accommodation as part of the employment process please contact: careers@axleinfo.com   Disclaimer: The above description is meant to illustrate the general nature of work and level of effort being performed by individual’s assigned to this position or job description. This is not restricted as a complete list of all skills, responsibilities, duties, and/or assignments required. Individuals may be required to perform duties outside of their position, job description or responsibilities as needed.
ID
2023-3794
Job Locations US-MT-Hamilton
Axle Informatics is a bioscience and information technology company that offers advancements in translational research, biomedical informatics, and data science applications to research centers and healthcare organizations around the globe. With experts in biomedical science, software engineering, and program management, we focus on developing and applying research tools and techniques to empower decision-making and accelerate research discoveries. We work with some of the top research organizations and facilities in the country including multiple institutes at the National Institutes of Health (NIH).   Overview Axle is seeking a highly ambitious, adaptable, structured, and detail-oriented Biologist  to join our vibrant team at the National Institutes of Health (NIH), National Institute of Allergy and Infectious Diseases (NIAID, Division of Intramural Research (DIR), Rocky Mountain Laboratories (RML). Responsibilities - Perform protein- and whole transcriptome-based spatial profiling, work on spatial profiling projects, execute the sample processing pipeline in coordination with the RTB teams. - Provide support for project management and coordination between multiple groups in transdisciplinary scientific approaches. - Perform laboratory techniques such as light microscopy, genomics technology, and/or digital pathology as applied to biological systems. - Process and optimization immunolabelling conditions of formalin-fixed, paraffin embedded and/or fresh frozen (cryostat) tissues. - Provide support in a core facility, including providing consultations to investigators and assisting with experimental design. - Provide maintenance of commercial microscopes and/or sequencing instrumentation, including working closely with commercial vendors to troubleshoot issues with instrumentation. - Serve as POC and participate in joint meetings with other spatial profiling team members across NIAID, NCI, as well as commercial vendors. Experience Required / Requirements - Minimum Master’s Degree (or Ph.D. – not required). - Minimum of four (4) years of work experience. - Good communication skills and ability to work in a team environment with co-workers. - Good record keeping and organizational skills. - Experience in spatial profiling techniques such as NanoString GeoMx DSP or 10X Visium would be an advantage but not required. - Work location: Rocky Montain Laboratory (RML), Montana   Benefits - 100% Medical, Dental & Vision premium coverage for Employees - Paid Time Off (Including Holidays) - Employee Referral Bonus - 401K Match - Tuition reimbursement and professional development opportunities - Flexible Spending Accounts: - Healthcare (FSA) - Parking Reimbursement Account (PRK) - Dependent Care Assistant Program (DCAP) - Transportation Reimbursement Account (TRN)     The diversity of Axle’s employees is a tremendous asset. We are firmly committed to providing equal opportunity in all aspects of employment and will not tolerate any illegal discrimination or harassment-based age, race, gender, religion, national origin, disability, marital status, covered veteran status, sexual orientation, status with respect to public assistance, and other characteristics protected under state, federal, or local law and to deter those who aid, abet, or induce discrimination or coerce others to discriminate.   Accessibility: If you need an accommodation as part of the employment process please contact: careers@axleinfo.com   Disclaimer: The above description is meant to illustrate the general nature of work and level of effort being performed by individual’s assigned to this position or job description. This is not restricted as a complete list of all skills, responsibilities, duties, and/or assignments required. Individuals may be required to perform duties outside of their position, job description or responsibilities as needed.
ID
2023-3793
Job Locations US-MD-Bethesda
Axle Informatics is a bioscience and information technology company that offers advancements in translational research, biomedical informatics, and data science applications to research centers and healthcare organizations nationally and abroad. With experts in biomedical science, software engineering, and program management, we focus on developing and applying research tools and techniques to empower decision-making and accelerate research discoveries. We work with some of the top research organizations and facilities in the country including multiple institutes at the National Institutes of Health (NIH).    Axle is seeking a highly ambitious, adaptable, structured, and detail-oriented Scientific Program Manager to join our vibrant team at the National Institutes of Health (NIH) supporting the National Institute on Aging (NIA) located in Bethesda, MD.    Deliverables: - Develops report on current status of clinical trial data metrics and includes recommendations for next steps - Monthly - Drafts findings and recommendations of analyses conducted using CROMS database - Monthly - Conducts, as needed, literature reviews to support the advancement of findings related to analytic reports generated by CROMS - Ad-Hoc Work Details: - Develops and assists staff implement policies and procedures related to the organization's scientific programs. - Design and support analysis of questionnaires, surveys, protocols, informed consent documents, training manuals, standard operating procedures (SOPs) and database management systems. - Perform study design, management, decision making, workgroup material reviews and presentations. - Collects, analyzes and creates scientific program information. - Plan, initiate, monitor and conduct administrative/portfolio analyses to evaluate the effectiveness of the program in meeting established goals. 1 - Coordinates workshops and reports their outcomes. - Attend and participate in multidisciplinary research team meetings and functions. - Evaluates current scientific programs and determines if changes need to be made. - Provide scientific evaluation and analysis to facilitate management of Programs related to bioinformatics and big data. 3 - Evaluate program activities to identify issues and develop recommendations for improvement. - Assists with analyzing current scientific programs and developing and proposing new initiatives. - Assist in conducting literature searches and provide summaries of findings as part of preliminary planning for new research activities and directions. - Work with staff on planning and implementing project-based activities; e.g., workshop planning, resource evaluation, communication strategy, assist with report writing/editing, etc. - Collaborates with management and prepares reports to keep them updated on new and ongoing programs and activities. - Contribute to the writing and development of executive summaries and reports to share with key partners. - Coordinates staff responsible for developing, installing and maintaining scientific programs. - Work with staff on the development and coordination of scientific initiatives. - Analyzes current policies and procedures and suggests and develops improvements. - Analyze and evaluate, on a quantitative and/or qualitative basis, the effectiveness of programs or operations in meeting established goals, measures and objectives. 2 - Assists in preparing and developing future strategic plans. - Prepare, a variety of routine and special reports on the research goals, current activities, accomplishments, and strategic planning efforts. - Provide analyses of scientific planning, evaluation, and/or policy questions or proposals for consideration by staff. - Prepares and provides educational materials to staff. - Develop and make readily available training materials to increase awareness about the program. - Works closely with management to develop new initiatives that further scientific research. - Collaborate with project lead to assess and make recommendations for appropriate initiatives and strategies to move forward; develop new initiatives. - Uses scientific expertise to review grant proposals and Interacts with potential grantees to obtain additional information. - Interact with scientists as needed to help overcome technical hurdles or provide additional insights or expertise regarding the preparation of scientific protocols. 1, 2, 3, 4, 5 represents priority rankings, where 1 is highest priority and 5 is lowest priority of those ranked     Minimum Education   Master's   Additional Qualifications:   Certifications & Licenses - Certified in Public Health   Field of Study - Community and Public Health Software - Demonstrates expertise with Microsoft MS Office Suite (Word, Excel, etc.) - Demonstrated expertise with statistical analysis program(s) Skills - Research conduct and compliance - Conduct of clinical research - Clinical trial and data collection - Knowledge of NIH grants and funding mechanims - Institutional Review Board (IRB) submissions - Training, Recruitment and retention       Benefits   - 100% Medical Dental & Vision Coverage for Employees - Educational Benefits for Career Growth - Paid Time Off (Including Holidays) - Employee Referral Bonus - Profit Sharing - 401K Matching - Flexible Spending Accounts: - Healthcare (FSA) - Parking Reimbursement Account (PRK) - Dependent Care Assistant Program (DCAP) - Transportation Reimbursement Account (TRN)   The diversity of Axle’s employees is a tremendous asset. We are firmly committed to providing equal opportunity in all aspects of employment and will not tolerate any illegal discrimination or harassment based on age, race, gender, religion, national origin, disability, marital status, covered veteran status, sexual orientation, status with respect to public assistance, and other characteristics protected under state, federal, or local law and to deter those who aid, abet, or induce discrimination or coerce others to discriminate.   Accessibility: If you need an accommodation as part of the employment process please contact: careers@axleinfo.com   Disclaimer: The above description is meant to illustrate the general nature of work and level of effort being performed by individual’s assigned to this position or job description. This is not restricted as a complete list of all skills, responsibilities, duties, and/or assignments required. Individuals may be required to perform duties outside of their position, job description or responsibilities as needed.
ID
2023-3789
Job Locations US-MD-Rockville
Axle Informatics is a bioscience and information technology company that offers advancements in translational research, biomedical informatics, and data science applications to research centers and healthcare organizations nationally and abroad. With experts in biomedical science, software engineering, and program management, we focus on developing and applying research tools and techniques to empower decision-making and accelerate research discoveries. We work with some of the top research organizations and facilities in the country including multiple institutes at the National Institutes of Health (NIH).    Axle is seeking a highly ambitious, adaptable, structured, and detail-oriented Scientific Program Manager to join our vibrant team at the National Institutes of Health (NIH) supporting the National Cancer Institute (NCI) located in Rockville, MD.    Overall Position Summary and Objectives This position will independently provide support services to satisfy the overall operational objectives of the NCI/DCEG.   Deliverables: - Work products and documents related to coordinate branch projects and data; coordinate epidemiologic study implementation and data collection; facilitate biospecimen acquisition, shipment, storage, tracking and distribution; maintain rigorous quality control of biospecimens, including collected data and related forms. - Ad-Hoc - Work products and documents related to troubleshooting and resolving operational problems; design and support analysis of questionnaires, surveys, protocols, informed consent documents, training manuals, standard operating procedures (SOPs) and database management systems. - Ad-Hoc - Work products and documents related to preparing data summaries, manuscripts, professional presentations and patient educational materials; edit written documents; attend and participate in multidisciplinary research team meetings and functions. - Ad-Hoc Work Details: - Coordinate branch projects and data. 1 - Coordinate epidemiologic study implementation and data collection, including liaison between CGB and collaborators in the US and abroad. 2 - Facilitate biospecimen acquisition, shipment, storage, tracking and distribution. 3 - Maintain rigorous qc of biospecimens, including collected data and related forms. - Design and support analysis of questionnaires, surveys, protocols, informed consent documents, training manuals, standard operating procedures (SOPs) and database management systems. - Coordinate submissions DCEG ethics review approvals. - Perform data cleaning (identifying and correcting data entry errors and/or missing values) and data transformation (creating and categorizing variables; inputting data) - Prepare data summaries, manuscripts, professional presentations and patient educational materials. - Edit written documents for stylistic, grammatical and typographical errors. - Attend and participate in multidisciplinary research team meetings and functions. 1, 2, 3, 4, 5 represents priority rankings, where 1 is highest priority and 5 is lowest priority of those ranked     Minimum Education   Master's   Additional Qualifications:   Certifications & Licenses - Master’s degree in Epidemiology or a related discipline - Minimum of four (4) years of related experience Field of Study - Miscellaneous Biology Software - Demonstrates expertise with Microsoft MS Office Suite (Word, Excel, etc.) Skills - Excellent analytical, organizational, interpersonal and time management skills - Strong communications skills, both oral and written - Strong data management and statistical skills. - Working knowledge of epidemiology, clinical research or biostatistics - Strong data management and statistical skills. - Working knowledge of human genetics or molecular genetics       Benefits   - 100% Medical Dental & Vision Coverage for Employees - Educational Benefits for Career Growth - Paid Time Off (Including Holidays) - Employee Referral Bonus - Profit Sharing - 401K Matching - Flexible Spending Accounts: - Healthcare (FSA) - Parking Reimbursement Account (PRK) - Dependent Care Assistant Program (DCAP) - Transportation Reimbursement Account (TRN)   The diversity of Axle’s employees is a tremendous asset. We are firmly committed to providing equal opportunity in all aspects of employment and will not tolerate any illegal discrimination or harassment based on age, race, gender, religion, national origin, disability, marital status, covered veteran status, sexual orientation, status with respect to public assistance, and other characteristics protected under state, federal, or local law and to deter those who aid, abet, or induce discrimination or coerce others to discriminate.   Accessibility: If you need an accommodation as part of the employment process please contact: careers@axleinfo.com   Disclaimer: The above description is meant to illustrate the general nature of work and level of effort being performed by individual’s assigned to this position or job description. This is not restricted as a complete list of all skills, responsibilities, duties, and/or assignments required. Individuals may be required to perform duties outside of their position, job description or responsibilities as needed.
ID
2023-3788
Job Locations US-MD
Axle Informatics is a bioinformatics and information technology company that offers innovative computer services, informatics, and enterprise solutions to research centers and healthcare organizations around the globe. With experts in software engineering, bioinformatics and program management, we focus on developing and applying technology tools and techniques to empower decision-making and accelerate the discovery in translational research. We work with some of the top research organizations and facilities in the country including multiple institutes at the National Institutes of health (NIH).   Axle Informatics is currently seeking an experienced Linux System Engineer/Administrator to join a Service Operations team supporting our federal client. The position is in North Bethesda, MD. (Hybrid)
ID
2023-3787
Job Locations US-MD-Rockville
We are seeking a SeniorBudget Analyst to join the team at Axle Informatics. The selected candidate will be responding to NIH budgetary requests, preparing reports, forecasts, and analyses for NIH customers as well tracking contract metrics including Earned Value Management. Axle Informatics is a bioscience and information technology company that offers advancements in translational research, biomedical informatics, and data science applications to research centers and healthcare organizations around the globe. With experts in biomedical science, software engineering, and program management, we focus on developing and applying research tools and techniques to empower decision-making and accelerate research discoveries. We work with some of the top research organizations and facilities in the country including multiple institutes at the National Institutes of Health (NIH). Responsibilities - Provides financial management over the NIH contract, subcontracts and program to control costs, schedule and performance of the prime contract. - Provides contract-level financial forecasting to include monthly, quarterly, and annual cost projections and scenario modeling to assess project changes. - Provides the centralized planning, direction, and control required to meet the cost, schedule, and performance goals throughout the life-cycle of the contract. - Review of all subcontract & consulting agreements to ensure financial compliance with company policies and federal, state, and local laws.  - Ensures assigned contracts are following and in compliance with Federal Acquisition Regulations, laws, standards, procedures.  - Proposes ways in which financial planning can be improved and/or processes can be streamlined.  Qualifications - 5-7 years of experience with General Budgeting MS Excel, MS Suite, Business Intelligence, Software Experience with earned value cost accounting and reporting. - Experience with metrics for assessing, analyzing, and reporting program cost variances and corrective actions. - Experience managing Time and Materials (T&M), Cost-plus-fixed-fee (CPFF), Cost-plus award Fee (CPAF) or Firm Fixed-Price (FFP) contract types - Proficient with developing program/project plans specifying goals, staffing, scheduling, identification of risks, contingency plans and, allocation of available resources.     Benefits  - 100% Medical, Dental & Vision premium coverage for Employees   - Paid Time Off (Including Holidays)  - Employee Referral Bonus   - 401K Match  - Tuition reimbursement and professional development opportunities  - Flexible Spending Accounts: - Healthcare (FSA) - Parking Reimbursement Account (PRK) - Dependent Care Assistant Program (DCAP) - Transportation Reimbursement Account (TRN)   The diversity of Axle’s employees is a tremendous asset. We are firmly committed to providing equal opportunity in all aspects of employment and will not tolerate any illegal discrimination or harassment based age, race, gender, religion, national origin, disability, marital status, covered veteran status, sexual orientation, status with respect to public assistance, and other characteristics protected under state, federal, or local law and to deter those who aid, abet, or induce discrimination or coerce others to discriminate.   Accessibility: If you need an accommodation as part of the employment process please contact: careers@axleinfo.com   Disclaimer: The above description is meant to illustrate the general nature of work and level of effort being performed by individual’s assigned to this position or job description. This is not restricted as a complete list of all skills, responsibilities, duties, and/or assignments required. Individuals may be required to perform duties outside of their position, job description or responsibilities as needed.  
ID
2023-3786
Job Locations US-MD-Bethesda
Axle Informatics is a bioscience and information technology company that offers advancements in translational research, biomedical informatics, and data science applications to research centers and healthcare organizations nationally and abroad. With experts in biomedical science, software engineering, and program management, we focus on developing and applying research tools and techniques to empower decision-making and accelerate research discoveries. We work with some of the top research organizations and facilities in the country including multiple institutes at the National Institutes of Health (NIH).    Axle is seeking a highly ambitious, adaptable, structured, and detail-oriented Scientist to join our vibrant team at the National Institutes of Health (NIH) supporting the National Institute of Neurological Disorders and Stroke (NINDS) located in Bethesda, MD.    Overall Position Summary and Objectives. Will independently serve as a Scientist to satisfy the overall operational objectives of the Developmental Therapeutics and Pharmacology Unit in the National Institute of Neurological Disorders and Stroke. The primary objective isadvance the science in the laboratory through new procedures and discoveries.   Deliverables: - Clean Equipment Daily - Run Validation - Daily - Inspect Equipment - Daily - Meet with lab members to present updates - Weekly - Maintain work documents and products - Daily Work Details: - Supports the planning and execution of research experiments in the context of the laboratory's overall research program. - Advance the science in the laboratory through new procedures and discoveries. 1 - Maintain and culture human and rodent cancer cell lines for in vitro experiments - Prepare human and rodent tumor cells for in vivo tumor implantations. - Assist when needed with animal work - Perform work on human specimens in support of ongoing clinical trials - Maintain and culture human and rodent cancer cell lines for in vitro experiments. Prepare human and rodent tumor cells for in vivo tumor implantations. - Assist when needed with animal work, including monitoring and treatment of tumor-bearing mice, handling mice for injection of tumor cells and drug treatments, intraperitoneal drug injections and oral gavage, tail vein injections, subcutaneous saline injections, measurement of tumors, weight checks, tumor harvest and assessment of health status. - Perform work on human specimens in support of ongoing clinical trials, including vessel/endothelial cell isolation, single cell disassociation of tumor tissue, rtPCR, PCR, western blots, immunohistochemistry, immune fluorescence, RNA-in situ hybridization, and others. - Maintain records of all experiments in laboratory notebook, including planning, execution, outcome and evaluation of experiments performed. - Order equipment and supplies in the NINDS ordering system, POTS - Assist with development of orders for large laboratory equipment. - Maintain and catalog recombinant DNA stocks, plasmids and vectors, flow cytometry antibody stocks and tissue bio- specimens. - Maintain stocks of available cancer cell lines in liquid nitrogen and update virtual inventory. - Work with staff to perform histology and histological labeling techniques including immunostaining  - Operate and troubleshoot laboratory equipment. - Analyze data and prepare presentations and present for NIH, regional and national meetings. - Work with staff on general laboratory maintenance, including clean water baths, prepare and keep tissue culture media stocked, check incubator temperature and CO2 levels; maintain tissue culture equipment and supplies • Maintain patient confidentiality - Supports laboratory staff on research projects and techniques. - Work with staff on the interpretation of experiments performed by research scientists. - Independently direct and conduct special research projects that have a high priority for the laboratory with special emphasis in the development of novel research treatments. - Review scientific data to determine if a research program can be developed around an idea or data package. - Maintains laboratory equipment and the training of others in their use. - Train staff on the proper usage of laboratory instruments and equipment. 2 - Calibrate, maintain and troubleshoot instruments and equipment in the laboratory. - Operate, troubleshoot and train others to use laboratory equipment and software. 3 - Provide advice and assistance to users in designing experiments, using instrumentation, data acquisition and analysis, and preparing figures for publication. - Assists in maintaining adequate space and facilities for ongoing and projected research studies. - Participate in the laboratory’s review of future proposals for resource allocations. - Evaluates, analyzes and interprets research data, communicates results and methods in reports, presentations, and manuscripts. - Write technical reports and prepare manuscripts. - Conduct bioinformatics data analyses and statistical analyses; prepare data for abstracts and manuscripts. Maintain a detailed and up-to-date electronic laboratory notebook detailing all experiments. - Responsible for data management for all processed compounds - Must ensure project data quality; analyze and interpret project data - Provides interpretation of results, guidance, and scientific support to the management team. - Provide scientific and technical expertise to all visiting fellows, post-docs, and technicians. 5 - Prepare data for authorship of manuscripts. - Coordinates with junior staff to modify research protocols. - Coordinate with IT staff on all software issues specific to the chemistry group and on all computer problems. - Identify and advise IC leadership on opportunities and program areas, research gaps and relevant program needs; make recommendations for consideration. - Mentors junior level scientists 4 - Attend laboratory meetings and present findings to staff. 1, 2, 3, 4, 5 represents priority rankings, where 1 is highest priority and 5 is lowest priority of those ranked     Minimum Education   Master’s   Additional Qualifications:     Certifications & Licenses - Neuroscience, Computer Science, Engineering, or related fields Field of Study - Neuroscience Software - Adobe Photoshop  - Adobe Pro  - Graph Pad Prism  - Microsof Skills - Ability to rapidly acquire knowledge in new fields and to understand and if necessary adapt published procedures to own needs.  - Ability to evaluate own results and those of others, including those in published literature.  - Proficiency in the operation of computer and general data acquisition programs.  - Excellent analytical, organizational, interpersonal, and time management skills - Background in molecular techniques, demonstrate ability to perform experiments independently and with minimal supervison.  - Strong communication skills, both oral and written       Benefits   - 100% Medical Dental & Vision Coverage for Employees - Educational Benefits for Career Growth - Paid Time Off (Including Holidays) - Employee Referral Bonus - Profit Sharing - 401K Matching - Flexible Spending Accounts: - Healthcare (FSA) - Parking Reimbursement Account (PRK) - Dependent Care Assistant Program (DCAP) - Transportation Reimbursement Account (TRN)   The diversity of Axle’s employees is a tremendous asset. We are firmly committed to providing equal opportunity in all aspects of employment and will not tolerate any illegal discrimination or harassment based on age, race, gender, religion, national origin, disability, marital status, covered veteran status, sexual orientation, status with respect to public assistance, and other characteristics protected under state, federal, or local law and to deter those who aid, abet, or induce discrimination or coerce others to discriminate.   Accessibility: If you need an accommodation as part of the employment process please contact: careers@axleinfo.com   Disclaimer: The above description is meant to illustrate the general nature of work and level of effort being performed by individual’s assigned to this position or job description. This is not restricted as a complete list of all skills, responsibilities, duties, and/or assignments required. Individuals may be required to perform duties outside of their position, job description or responsibilities as needed.  
ID
2023-3782
Job Locations US-MD-Rockville
Axle Informatics is a scientific research and information technology company that offers innovative computer services, informatics, and bioresearch solutions to research centers and healthcare organizations around the globe. With expertise in software engineering, bioinformatics, data science, molecular research, and program management, we focus on developing and applying technological tools and scientific techniques to empower the world of research. We work with some of the top research organizations and facilities in the country including multiple institutes at the National Institutes of Health (NIH). Axle is offering this postion hybrid. 
ID
2023-3781
Job Locations US-MD-Rockville
Axle Informatics is a scientific research and information technology company that offers innovative computer services, informatics, and bioresearch solutions to research centers and healthcare organizations around the globe. With expertise in software engineering, bioinformatics, data science, molecular research, and program management, we focus on developing and applying technological tools and scientific techniques to empower the world of research. We work with some of the top research organizations and facilities in the country including multiple institutes at the National Institutes of Health (NIH). Axle is offering this position hybrid.    Our software engineering teams leverage agile development principles, advanced development and design practices, and DevOps automation to rapidly develop and deliver modern, high-quality solutions. As a software development engineer trainee, you'll support development of applications that are helping to advance critical medical research. This experience will give you valuable real-world development skills and experience, while supporting the research community.   The 12-week trainee program provides emerging talent with hands-on experience in all aspects of software development.  These include agile/scrum practices, requirements and design, testing automation, application security, and DevOps culture of continuous integration and deployment.  
ID
2023-3780
Job Locations US-MD-Rockville
Axle Informatics is a bioscience and information technology company that offers advancements in translational research, biomedical informatics, and data science applications to research centers and healthcare organizations nationally and abroad. With experts in biomedical science, software engineering, and program management, we focus on developing and applying research tools and techniques to empower decision-making and accelerate research discoveries. We work with some of the top research organizations and facilities in the country including multiple institutes at the National Institutes of Health (NIH).    Axle is seeking a highly ambitious, adaptable, structured, and detail-oriented Biologist to join our vibrant team at the National Institutes of Health (NIH) supporting the National Center for Advancing Translational Sciences (NCATS) located in Rockville, MD.    Overall Position Summary and Objectives Under this task order, the contractor will independently provide support services to satisfy the overall operational objectives of the program. The primary objective is to provide services and deliverables through performance of support services.   Deliverables: - Work products and documents related to developing and optimizing antibody and antibody-drug conjugate discovery technologies; analyze experimental results; organize findings into tables and figures. - Daily - Work products and documents related to evaluating new technologies and instruments; search literature; propose, design and test alternative assays; confirm assay results; determine EC50/specificity; develop secondary assays. - Daily - Work products and documents related to operating liquid dispensing systems; test assays for utilization of probe candidates; propose and investigate new target projects. - Daily - Work products and documents related to maintaining and updating notebooks and instruments; prepare technical reports, summaries and manuscripts; prepare oral presentations and posters. - Daily Work Details: - Provides technical experience needed to assist in studying the basic principles of plant and animal life - Develop and optimize antibody discovery platforms, such as phage display, affinity maturation, protein evolution, functional selection by high-throughput cell sorting, etc. 1 - Develop and optimize methodologies for production of novel antibody-drug conjugates. 2 - Develop and employ cutting-edge technologies to optimize properties of antibodies, such as affinity and selectivity, solubility, scalability of production, and pharmacokinetic profile. 3 - Assists with performing basic laboratory experiments and procedures - Analyze the experimental results and organize findings into tables and figures. 4 - Evaluate new technologies and instruments resulting in proposals for new screening strategies and novel formats. 5 - Propose, design and test assays to allow for a secondary profiling and utilization of probe candidates. - Propose and investigate new target projects for initiation based on novelty and relevance to human health. - Write technical and experimental reports. - Collaborate with investigators to prepare manuscripts for publication. - Prepare oral presentations and posters for internal and external groups and conferences. - Provide updates to assay providers; send summaries; conduct periodical teleconferences to discuss issues and coordinate actions. - Prepares, organizes and maintains various lab samples, supplies, and equipment - Operate liquid dispensing systems (Aurora FRD, Kalypsys dispenser and pintool, CyBio Cybi Well, PE Evolution P3) and multimodal detectors/plate readers (Tecan Safire, PE ViewLux, PE EnVision), - Analyze the experimental results and organize them into tables and figures with Prism Plot and other data analysis/visualization software. - Learns new laboratory techniques and procedures - Search existing literature; propose, design and test alternative assays for difficult screening targets. - Confirm assay results and determine EC50/specificity for primary active samples; develop secondary assays for follow-up; communicate results to facilitate antibody probe development. - Maintain and update laboratory notebooks and instruments. 1, 2, 3, 4, 5 represents priority rankings, where 1 is highest priority and 5 is lowest priority of those ranked     Minimum Education   Master's   Additional Qualifications:   Certifications & Licenses - Ph.D. degree in a scientific field. Three (3) years of specialized experience plus a Master’s degree is equivalent to a Ph.D. Five (5) years of specialized experience plus a Bachelor’s degree is equivalent to a Ph.D. - Two (2) years of experience in a science related field. Demonstrates expert knowledge working in the research laboratory environment. Computer skills to include MS Office Suite. Field of Study - Biochemical Sciences Software - Computer skills to include MS Office Suite. Skills - Experience working in research laboratory environment. - Excellent analytical, organizational and time management skills. - Strong communications skills, both oral and written.         Benefits   - 100% Medical Dental & Vision Coverage for Employees - Educational Benefits for Career Growth - Paid Time Off (Including Holidays) - Employee Referral Bonus - Profit Sharing - 401K Matching - Flexible Spending Accounts: - Healthcare (FSA) - Parking Reimbursement Account (PRK) - Dependent Care Assistant Program (DCAP) - Transportation Reimbursement Account (TRN)   The diversity of Axle’s employees is a tremendous asset. We are firmly committed to providing equal opportunity in all aspects of employment and will not tolerate any illegal discrimination or harassment based on age, race, gender, religion, national origin, disability, marital status, covered veteran status, sexual orientation, status with respect to public assistance, and other characteristics protected under state, federal, or local law and to deter those who aid, abet, or induce discrimination or coerce others to discriminate.   Accessibility: If you need an accommodation as part of the employment process please contact: careers@axleinfo.com   Disclaimer: The above description is meant to illustrate the general nature of work and level of effort being performed by individual’s assigned to this position or job description. This is not restricted as a complete list of all skills, responsibilities, duties, and/or assignments required. Individuals may be required to perform duties outside of their position, job description or responsibilities as needed.
ID
2023-3779
Job Locations US-MD-Bethesda
Axle Informatics is a bioscience and information technology company that offers advancements in translational research, biomedical informatics, and data science applications to research centers and healthcare organizations nationally and abroad. With experts in biomedical science, software engineering, and program management, we focus on developing and applying research tools and techniques to empower decision-making and accelerate research discoveries. We work with some of the top research organizations and facilities in the country including multiple institutes at the National Institutes of Health (NIH).    Axle is seeking a highly ambitious, adaptable, structured, and detail-oriented Patient Care Coordinator to join our vibrant team at the National Institutes of Health (NIH) supporting the National Institute of Neurological Disorders and Stroke (NINDS) located in Bethesda, MD.    Overall Position Summary and Objectives Purpose of this position is to support the Clinical Neurosurgery Unit within the Surgical Neurology Branch of NINDS.   Deliverables: - Meet with clinical team to discuss patients and scheduling - Weekly - Meet with patient care coordinators to discuss operations and procedures - Monthly - Answers clinic line and directs calls appropriately - Daily - Schedules and finalizes in-patient and out-patient appointments - Daily - Maintains timely email communications - Daily - Sorts Clinic related mail and files/scans all paperwork - Daily Work Details: - Coordinates the recruitment, scheduling, travel and admission of research study participants. - Coordinate patient schedules with testers, nurses, physicians and clinical research coordinators. 1 - Act as primary point of contact for patients enrolled in the study. - Coordinate the recruitment, scheduling, travel and admission of research study participants with clinical staff. - Work with staff to coordinate new research patient screening appointments, procedures and imaging studies between protocol investigators and the outpatient clinic scheduling personnel. - Coordinate scheduling, travel and lodging of subjects participating in studies. 5 - Review incoming patient referrals and contact referring physician’s office if referral is incomplete - Distributes recruitment materials. - Distribute patient recruitment and communication materials. - Distribute fliers, research and place advertisements in suitable media. - Acts as a liaison between participants, participant's relatives and staff members and communicates participant's questions, complaints, problems and concerns to appropriate staff members. - Triage questions to appropriate personnel in the team as necessary. 4 - Maintain ongoing relationships with patients, families, caregivers, medical care providers and various individuals on a continuous long-term basis. - Respond to patient emails and phone calls; prioritize patient related issues into urgent, emergent and routine; triage the issues to the appropriate personnel in the team as necessary. 2 - Explains policies and procedures to participants and refers them to appropriate staff. - Serve as point of contact for questions, advice and communications on the process and status of protocols; initiate and respond to correspondence and telephone contacts pertaining to admission of patients. - Respond to communications with research subjects; direct questions to appropriate team member. - Communicates with participants regarding policy and procedures for joining studies for NIH. - Collates, enters and maintains data collected on participants. - Collect outside medical documentation, electronically scans and uploads records into the electronic medical record. - Collate and enter data collected on participants. - Review medical records to collect relevant clinical data. - Ensure accurate and complete collection and submission of study data. - Maintain patient files, medical records, and patient family contacts; file medical record notes into patient charts daily. - Maintain clinical data in protocol databases. - Create reports/spreadsheets for tracking and scheduling of protocol patients. - Review patient and clinical charts; enter patient data into files and automated databases. 3 - Ensure that research data are entered into database. - Ensure consistency in records, data and datasets in accordance with regulatory requirements. - Work with staff on QA/QC of the clinical and research records for patients on study prior to audits. - Obtain medical information, imaging disks and pictures from applicants on an ongoing basis; file them with the records. 1, 2, 3, 4, 5 represents priority rankings, where 1 is highest priority and 5 is lowest priority of those ranked     Minimum Education   Associate's   Additional Qualifications:   Field of Study - General Medical and Health Services Software - Electronic Medical records - Microsoft Suite Skills - Maintain client communication regarding data management project status and review key project questions with clients, working in a hospital setting - Possess proficiency with clinical databases and report tools         Benefits   - 100% Medical Dental & Vision Coverage for Employees - Educational Benefits for Career Growth - Paid Time Off (Including Holidays) - Employee Referral Bonus - Profit Sharing - 401K Matching - Flexible Spending Accounts: - Healthcare (FSA) - Parking Reimbursement Account (PRK) - Dependent Care Assistant Program (DCAP) - Transportation Reimbursement Account (TRN)   The diversity of Axle’s employees is a tremendous asset. We are firmly committed to providing equal opportunity in all aspects of employment and will not tolerate any illegal discrimination or harassment based on age, race, gender, religion, national origin, disability, marital status, covered veteran status, sexual orientation, status with respect to public assistance, and other characteristics protected under state, federal, or local law and to deter those who aid, abet, or induce discrimination or coerce others to discriminate.   Accessibility: If you need an accommodation as part of the employment process please contact: careers@axleinfo.com   Disclaimer: The above description is meant to illustrate the general nature of work and level of effort being performed by individual’s assigned to this position or job description. This is not restricted as a complete list of all skills, responsibilities, duties, and/or assignments required. Individuals may be required to perform duties outside of their position, job description or responsibilities as needed.
ID
2023-3778
Job Locations US-MD-Rockville
Axle Informatics is a bioscience and information technology company that offers advancements in translational research, biomedical informatics, and data science applications to research centers and healthcare organizations around the globe. With experts in biomedical science, software engineering, and program management, we focus on developing and applying research tools and techniques to empower decision-making and accelerate research discoveries. We work with some of the top research organizations and facilities in the country including multiple institutes at the National Institutes of Health (NIH).   Overview Axle is seeking a highly ambitious, adaptable, structured, and detail-oriented Program Analyst to join our vibrant team at Rockville, MD. Responsibilities - Assist in the liaison with HHS, CDC and other U.S. Government (USG) agencies for the coordination of support for overseas assignments and other programmatic responsibilities. - Assist in providing accurate, well-written communication that is audience-appropriate to outside organizations regarding activities of NIH staff. - Interpret guidance and policy documents addressing overseas workforce activities to write and develop documentation to support NIH. - Assist in preparing and reviewing statements of work, proposals, and other documentation to be used by management in procurement actions. - Develop and maintain spreadsheets and/or other administrative databases related to program, project and personnel activities. - Gather and analyze information related to budget, processes, and programs; prepare well-written, comprehensive reports, letters, background papers, and other documents for review and input for programs, policies, and activities. Report and identify problem areas that will be used by senior staff for making decisions to formulate budgets, manage programs and other overseas activities. - Assist in preparing background materials, briefing documents and position papers for presentation or use by senior NIH officials. - Assist in developing guidelines and procedures for monitoring international programs’ activities. - Assist in establishing, modifying and updating standard operating procedures and other correspondence management, status reporting and records management. - Assist as needed with the coordination and arrangement of meetings and workshops. - Represent the office at meetings with NIH and HHS offices in the areas of administrative, technical, and budgetary topics related to international programs and overseas staff support. - Assist with the development of proposals, coordination, and maintenance of research collaboration agreements developed in concurrence with outside institutions and foreign research institutions to carry out research activities in support of NIH research initiatives. Experience Required / Requirements - All support positions require a minimum of a BS degree; MS or MBA is preferred. - Familiarity with inter-governmental agencies interactions preferred. - Ability to interpret and analyze Program / Project policy documents is required. - Detail Oriented, ability to perform well with minimal supervision. - Experience with Microsoft Office Suite, including Word, Excel, PowerPoint, SharePoint, Teams, OneDrive, software products required. - Excellent interpersonal, oral and written communication skills required. - Familiarity with NIH and biomedical research supported by the U.S. Government is highly desirable. Benefits - Paid Time Off (PTO) - 10 Paid Federal holidays - Generous health coverage provided with no monthly premium to the employee - Generous vision and dental coverage provided with no monthly premium to the employee - Short and Long-Term Disability coverage (paid by company) - Basic Life and AD&D coverage (paid by company; option to purchase additional coverage) - 401(K) with significant company match & no vesting period - Competitive salaries with performance bonus opportunities - Discount plan for pet care, legal services, & identify theft protection - Flexible Spending Accounts: - Healthcare (FSA) - Parking Reimbursement Account (PRK) - Dependent Care Assistant Program (DCAP) - Transportation Reimbursement Account (TRN)   The diversity of Axle’s employees is a tremendous asset. We are firmly committed to providing equal opportunity in all aspects of employment and will not tolerate any illegal discrimination or harassment based age, race, gender, religion, national origin, disability, marital status, covered veteran status, sexual orientation, status with respect to public assistance, and other characteristics protected under state, federal, or local law and to deter those who aid, abet, or induce discrimination or coerce others to discriminate.   Accessibility: If you need an accommodation as part of the employment process please contact:  Email: careers@axleinfo.com   Disclaimer: The above description is meant to illustrate the general nature of work and level of effort being performed by individual’s assigned to this position or job description. This is not restricted as a complete list of all skills, responsibilities, duties, and/or assignments required. Individuals may be required to perform duties outside of their position, job description or responsibilities as needed.
ID
2023-3777
Job Locations US-MD-Bethesda
Axle Informatics is a bioscience and information technology company that offers advancements in translational research, biomedical informatics, and data science applications to research centers and healthcare organizations nationally and abroad. With experts in biomedical science, software engineering, and program management, we focus on developing and applying research tools and techniques to empower decision-making and accelerate research discoveries. We work with some of the top research organizations and facilities in the country including multiple institutes at the National Institutes of Health (NIH).    Axle is seeking a highly ambitious, adaptable, structured, and detail-oriented Biostatistician to join our vibrant team at the National Institutes of Health (NIMHD) located in Bethesda, MD.    Deliverables: - Provide consultation on statistical analysis and methods; perform data cleaning and formatting, data harmonization, and data analyses; and prepare results for publication from clinical trials, experimental and observational studies, interventional studies, and secondary data analysis projects based on nationally representative and non-representative data and medical/hospital data. - Develop and implement methods and procedures for the collection, processing, compilation, cleaning, and analysis of data. - Evaluate new statistical procedures and software and adapt them as necessary. - Interpret and communicate results of analyses in written and oral formats and generate tabular presentations and graphical visualizations of the data. - Generate and maintain an annotated database of all raw and analytic datasets and create and update documentation on variables in analytic datasets (i.e., data dictionary). - Collaborate with lab members on aspects of study design, analysis, and interpretation, and work closely with the research team on writing research protocols, grant proposals, and manuscripts. - Attend lab meetings and work as an integrated team member. - Support fellows in the lab on statistical analyses, research methods, and study designs. - Perform other research support activities as needed   Benefits   - 100% Medical Dental & Vision Coverage for Employees - Educational Benefits for Career Growth - Paid Time Off (Including Holidays) - Employee Referral Bonus - Profit Sharing - 401K Matching - Flexible Spending Accounts: - Healthcare (FSA) - Parking Reimbursement Account (PRK) - Dependent Care Assistant Program (DCAP) - Transportation Reimbursement Account (TRN)   The diversity of Axle’s employees is a tremendous asset. We are firmly committed to providing equal opportunity in all aspects of employment and will not tolerate any illegal discrimination or harassment based on age, race, gender, religion, national origin, disability, marital status, covered veteran status, sexual orientation, status with respect to public assistance, and other characteristics protected under state, federal, or local law and to deter those who aid, abet, or induce discrimination or coerce others to discriminate.   Accessibility: If you need an accommodation as part of the employment process please contact: careers@axleinfo.com   Disclaimer: The above description is meant to illustrate the general nature of work and level of effort being performed by individual’s assigned to this position or job description. This is not restricted as a complete list of all skills, responsibilities, duties, and/or assignments required. Individuals may be required to perform duties outside of their position, job description or responsibilities as needed.
ID
2023-3776
Job Locations US-MD-Rockville
 Axle Informatics is a scientific research and information technology company that offers innovative computer services, informatics, and bioresearch solutions to research centers and healthcare organizations around the globe. With expertise in software engineering, bioinformatics, data science, molecular research, and program management, we focus on developing and applying technological tools and scientific techniques to empower the world of research. We work with some of the top research organizations and facilities in the country including multiple institutes at the National Institutes of Health (NIH).    The National Center for Advancing Translational Sciences (NCATS) works towards transforming the translational process so that new treatments and cures for disease can be delivered to patients faster. Translation is the process of turning observations in the laboratory, clinic and community into interventions that improve the health of individuals and the public. NCATS proposes to transform chemistry from an individualized craft to a modern, information-based science through A Specialized Platform for Innovative Research Exploration (ASPIRE). ASPIRE builds on the power of recent and emerging technological innovations. The convergence of technologies like laboratory automation, high throughput screening and machine learning, provides a new opportunity to break translational bottlenecks in chemistry and benefit science and health.   Internship Program at Axle Informatics/NCATS  The recruiting team is driven by the passion to recognize emerging talent. Our program places the best students in positions that they will grow both technically and personally through their experience working closely with their Manager, Mentor, and team. We are dedicated to providing an experience that allows for the intern to experience life at NCATS by giving them projects that are critical to their team’s success. Instead of going on coffee runs and making copies, you’ll be seated at the table making critical decisions that will influence not only your team, but the overall achievement of NCATS’s mission.   About the team  The Engineering team is in charge of helping NCATS develop automation products, optimize product design and validate the most compelling automation systems for our customers. For this purpose, the team is responsible for both designing, building, and deploying robotics and automated equipment, and to support current and future products and collecting data to enable their reliability and functionality.
ID
2023-3775
Job Locations US-MD-Rockville
Axle Informatics is a scientific research and information technology company that offers innovative computer services, informatics, and bioresearch solutions to research centers and healthcare organizations around the globe. With expertise in software engineering, bioinformatics, molecular research, data science, and program management, we focus on developing and applying technological tools and scientific techniques to empower the world of research. We work with some of the top research organizations and facilities in the country including multiple institutes at the National Institutes of Health (NIH).   We are looking for Data Science Trainees to support portions of engineering based Data Science projects which Axle Informatics teams are working on currently at the National Center for Advancing Translational Science (NCATS) and the NIH.  
ID
2023-3774
Job Locations US
 Axle Informatics is a scientific research and information technology company that offers innovative computer science services, informatics, and bioresearch solutions to research centers and healthcare  organizations around the globe. With expertise in software engineering, robotics engineering, bioinformatics, data science molecular research, and program management, we focus on developing and applying technological tools and scientific techniques to empower the world of research. We work with some of the top research organizations and facilities in the country including multiple institutes at the National Institutes of Health (NIH).     The Engineering team is in charge of helping NCATS develop automation products, optimize product design and validate the most compelling automation systems for our clients . The intern will work cross-functionally with the automation engineers, chemists, biologists, and IT and help support various engineering and scientific teams throughout the whole design cycle of a given system. The intern will be expected to learn fast, solve problems in a fundamental way, and communicate internally and externally to drive decision making. The intern will be working on development and integration of systems that include robotic arms, mobile robots, linear actuators, computer vision, sensors, etc. They will also be working on development of software written in Python capable of operating said systems.   Internship Program at Axle Informatics/NCATS  The recruiting team is driven by the passion to recognize emerging talent. Our program places the best students in positions that they will grow both technically and personally through their experience working closely with their Manager, Mentor, and team. We are dedicated to providing an experience that allows for the intern to experience life at NCATS by giving them projects that are critical to their team’s success. Instead of going on coffee runs and making copies, you’ll be seated at the table making critical decisions that will influence not only your team, but the overall achievement of NCATS’s mission.   About the team  The Engineering team is in charge of helping NCATS develop automation products, optimize product design and validate the most compelling automation systems for our customers. For this purpose, the team is responsible for designing, building, and deploying robotics and automated equipment to support current and future products and collecting data to enable their reliability and functionality.
ID
2023-3773
Job Locations US-MD-Bethesda
Axle Informatics is a bioscience and information technology company that offers advancements in translational research, biomedical informatics, and data science applications to research centers and healthcare organizations nationally and abroad. With experts in biomedical science, software engineering, and program management, we focus on developing and applying research tools and techniques to empower decision-making and accelerate research discoveries. We work with some of the top research organizations and facilities in the country including multiple institutes at the National Institutes of Health (NIH).    Axle is seeking a highly ambitious, adaptable, structured, and detail-oriented Scientist to join our vibrant team at the National Institutes of Health (NIH) supporting the National Institute of Neurological Disorders and Stroke (NINDS) located in Bethesda, MD.    Overall Position Summary and Objectives The purpose of this position is to conduct independent investigation in addition to providing scientific and technical guidance to members of the lab.   Deliverables: - Produce electron microscopy data for both independent projects and in support of other lab members projects for publication in high quality journals - Bi-Weekly - Meet with lab members to present updates - Quarterly Work Details: - Supports the planning and execution of research experiments in the context of the laboratory's overall research program. - Evaluate new techniques, instruments, and software for potential incorporation into current SOP. - Advance the science in the laboratory through new procedures and discoveries. 1 - Design and conduct experiments and studies requiring the application of a broad professional knowledge of scientific theories and principles. 2 - Oversee a state-of-the-art core facility serving the NIH community; review associated budget. - Advance the science through proposing and investigating new target projects for initiation based on novelty and relevance to human health. - Supports laboratory staff on research projects and techniques. - Work with staff on the interpretation of experiments performed by research scientists. - Independently direct and conduct special research projects that have a high priority for the laboratory with special emphasis in the development of novel research treatments. 3 - Work with postdoc/biological scientists to perform statistical analysis for research projects. - Work with staff on assay design and method development using an array or experimentation. - Maintains laboratory equipment and the training of others in their use. - Train staff on the proper usage of laboratory instruments and equipment. - Calibrate, maintain and troubleshoot instruments and equipment in the laboratory. - Operate, troubleshoot and train others to use laboratory equipment and software. - Provide advice and assistance to users in designing experiments, using instrumentation, data acquisition and analysis, and preparing figures for publication. - Assists in maintaining adequate space and facilities for ongoing and projected research studies. - Manage scientific equipment and resources (e.g. reagents, stocks of frozen sells, animal samples) including acquisition, documentation and storage. - Evaluates, analyzes and interprets research data, communicates results and methods in reports, presentations, and manuscripts. - Write technical reports and prepare manuscripts. 4 - Oversee project data quality; analyze and interpret project data. - Maintain a detailed and up-to-date electronic laboratory notebook detailing all experiments. - Coordinates with junior staff to modify research protocols. - Work with staff to confirm assay results and evaluate new techniques and instruments; search literature; propose, design and test alternative assays for difficult screening targets; confirm assay results; develop secondary assays. - Suggest alternative or complementary approaches to experiments. - Presents research at national scientific meetings and symposia. - Prepare oral presentations and posters for internal and external groups/conferences. - Co-author manuscripts on research projects; publish in peer-reviewed journals. - Write papers and abstracts detailing research efforts and results for publication in peer-reviewed journals; prepare - PowerPoint presentations as appropriate. - Give posters and presentations detailing work at regional and national scientific meetings. - Review, edit, and, as needed, write first drafts of papers, posters and manuscripts. 5 - Give posters and presentations detailing work at regional and national scientific meetings. - Present results of clinical and experimental research at recognized scientific meetings by lectures and exhibits (poster sessions). - Provides interpretation of results, guidance, and scientific support to the management team. - Search existing literature for new and/or relevant techniques. - Assist the lab staff in the creation and preparation of a variety of documents required by the lab’s scientific activities. - Produce research reports and regularly communicate results to staff and collaborators. - Mentors junior level scientists. - Train staff on the proper usage of equipment. - Train staff in a wide variety of techniques used in the laboratory. - Coordinate training of users in applying data and analysis methods for their research studies. - Provide scientific and technical expertise to all visiting fellows, post-docs, and technicians. - Train laboratory staff to independently run the experiments and analyze the data. 1, 2, 3, 4, 5 represents priority rankings, where 1 is highest priority and 5 is lowest priority of those ranked     Minimum Education   Master's   Additional Qualifications:   Certifications & Licenses - Biosafety Level 2 (BSL 2) Field of Study - Neuroscience - Physiology Software - Excel - FIJI Skills - Equipment Maintenance - Manuscript writing - Tissue Sectioning - Data Presentation - Cryosectioning - Data Analysis - Bacterial Culture - Cell culture - Plunge freezing for cryo EM - Freeze substitution for cryo EM - Epon embedding and ultramicrotome sectioning for EM - Serial sectioning for electron microscopy - Transmission electron microscopy imaging - Correlative light and electron microscopy       Benefits   - 100% Medical Dental & Vision Coverage for Employees - Educational Benefits for Career Growth - Paid Time Off (Including Holidays) - Employee Referral Bonus - Profit Sharing - 401K Matching - Flexible Spending Accounts: - Healthcare (FSA) - Parking Reimbursement Account (PRK) - Dependent Care Assistant Program (DCAP) - Transportation Reimbursement Account (TRN)   The diversity of Axle’s employees is a tremendous asset. We are firmly committed to providing equal opportunity in all aspects of employment and will not tolerate any illegal discrimination or harassment based on age, race, gender, religion, national origin, disability, marital status, covered veteran status, sexual orientation, status with respect to public assistance, and other characteristics protected under state, federal, or local law and to deter those who aid, abet, or induce discrimination or coerce others to discriminate.   Accessibility: If you need an accommodation as part of the employment process please contact: careers@axleinfo.com   Disclaimer: The above description is meant to illustrate the general nature of work and level of effort being performed by individual’s assigned to this position or job description. This is not restricted as a complete list of all skills, responsibilities, duties, and/or assignments required. Individuals may be required to perform duties outside of their position, job description or responsibilities as needed.
ID
2023-3771
Job Locations US-MD-Rockville
Axle Informatics is a scientific research and information technology company that offers innovative computer services, informatics, and bioresearch solutions to research centers and healthcare organizations around the globe. With expertise in software engineering, bioinformatics, data science, molecular research, and program management, we focus on developing and applying technological tools and scientific techniques to empower the world of research. We work with some of the top research organizations and facilities in the country including multiple institutes at the National Institutes of Health (NIH). Axle is offering this postion hybrid.    We are looking for Data Science Trainees to support portions of engineering based Data Science projects which Axle Informatics teams are working on currently at the National Center for Advancing Translational Science (NCATS) and the NIH.  
ID
2023-3770
Job Locations US-MD-Bethesda
Axle Informatics is a bioscience and information technology company that offers advancements in translational research, biomedical informatics, and data science applications to research centers and healthcare organizations nationally and abroad. With experts in biomedical science, software engineering, and program management, we focus on developing and applying research tools and techniques to empower decision-making and accelerate research discoveries. We work with some of the top research organizations and facilities in the country including multiple institutes at the National Institutes of Health (NIH).    Axle is seeking a highly ambitious, adaptable, structured, and detail-oriented Laboratory Mouse Technician to join our vibrant team at the National Institutes of Health (NIH) supporting the National Institute of Neurological Disorders and Stroke (NINDS) located in Bethesda, MD.    Overall Position Summary and Objectives The mission of our laboratory is to understand the role of the spinal cord in movement. The purpose of this position is to support mouse work within our laboratory, including mouse colony maintenance, post-surgical animal care, and tissue processing.   Deliverables: - Meet with lab members to present updates - Weekly Work Details: - Provides laboratory experience needed to maintain experimental animal colonies and collect sequential colony census. - Conduct small animal husbandry, animal handling, and specific procedures. 2 - Interpret genotyping results and maintain genotyping records. - Perform genotyping PCR to maintain transgenic mouse colonies used in projects, including images of genotyping PCR gels and tabulation of genotyping results. 4 - Perform laboratory and animal technical duties to include, but not limited to: weighing animals and feed, blood withdrawals, performing injections, operating behavioral equipment. - Perform maintenance of large breeding colonies; maintain small animal colonies including handling of animals for hormone injection, mating, timed mating, and other experimental procedures; and update and maintain records of breeding colonies, ear identification, mating of breeding pairs, fostering and establishment of timed pregnancies. 1 - Harvest and collect animal embryos, tissues, and organs. - Perform mating, checking for estrus, weaning, tail clipping, animal identification, fostering of pups and euthanasia. 3 - Prepares / monitors caging environments and animal health. - Report any animal health, care, and/or well-being concerns to the appropriate facility management staff and facility veterinarians. - Ensure the humane treatment of animals in the laboratory. - Collaborates with veterinarians in the performance of animal surgeries. - Prepare animals for surgery including vascular catheterization, post-surgical care, assessment of physiological status, application of in vivo quantitative tracer imaging techniques, sacrificing animals, brain removal and dissection, and collection. - Prepare animals for surgery and ensure proper disposal of animal carcasses. - Handle, dissect and euthanize animals. - Maintains detailed and accurate records. - Track and maintain database for all research activities; update and maintain laboratory notebooks and databases; and record procedures performed in laboratory notebook. - Assists with organizing the shipment of mice to and from facility. - Work with staff on organizing the animal shipment to and from the facility. - Maintains records of animal protocols. - Perform and maintain records of molecular biology protocols. - Maintains laboratory stock of reagents and materials. - Perform routine laboratory maintenance including laboratory stock of reagents and materials. - Performs experimental procedures as well as standardized and specialized tests, exams and vaccinations. - Prepare animals for experiments. - Perform procurement, processing, and preservation of specimens so as to maintain sample identification and prevention of cross contamination. - Trains other in proper animal handing and surgical procedures. - Provide technical guidance and assistance for researchers interested in well-established protocols. 1, 2, 3, 4, 5 represents priority rankings, where 1 is highest priority and 5 is lowest priority of those ranked     Minimum Education   High School   Additional Qualifications:   Field of Study - Biology Skills - Mouse colony maintenance     Benefits   - 100% Medical Dental & Vision Coverage for Employees - Educational Benefits for Career Growth - Paid Time Off (Including Holidays) - Employee Referral Bonus - Profit Sharing - 401K Matching - Flexible Spending Accounts: - Healthcare (FSA) - Parking Reimbursement Account (PRK) - Dependent Care Assistant Program (DCAP) - Transportation Reimbursement Account (TRN)   The diversity of Axle’s employees is a tremendous asset. We are firmly committed to providing equal opportunity in all aspects of employment and will not tolerate any illegal discrimination or harassment based on age, race, gender, religion, national origin, disability, marital status, covered veteran status, sexual orientation, status with respect to public assistance, and other characteristics protected under state, federal, or local law and to deter those who aid, abet, or induce discrimination or coerce others to discriminate.   Accessibility: If you need an accommodation as part of the employment process please contact: careers@axleinfo.com   Disclaimer: The above description is meant to illustrate the general nature of work and level of effort being performed by individual’s assigned to this position or job description. This is not restricted as a complete list of all skills, responsibilities, duties, and/or assignments required. Individuals may be required to perform duties outside of their position, job description or responsibilities as needed.
ID
2023-3769