Axle Informatics

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Job Locations US-MD-Rockville
Axle Informatics is a bioscience and information technology company that offers advancements in translational research, biomedical informatics, and data science applications to research centers and healthcare organizations around the globe. With experts in biomedical science, software engineering, and program management, we focus on developing and applying research tools and techniques to empower decision-making and accelerate research discoveries. We work with some of the top research organizations and facilities in the country including multiple institutes at the National Institutes of Health (NIH).   Overview Axle is seeking a highly ambitious, adaptable, structured, and detail-oriented Scientific Program Manager to join our vibrant team at the National Institutes of Health (NIH), National Institute of Allergy and Infectious Diseases (NIAID), Division of AIDS (DAIDS), Vaccine Research Program (VRP), Vaccine Translational Research Branch (VTRB), Rockville, MD. Responsibilities - Work with federal staff responsible for cGMP product development of vaccines for infectious diseases including the production of investigational products that are identified as strong candidates to move from a preclinical to clinical phase. - Plan, organize, and coordinate cGMP activities across all project stakeholders. Set deadlines, record responsibilities, monitor and summarize progress of various cGMP manufacturing projects. - Participate as a team member in a group composed of different staffing areas including scientific/technical roles, project management, regulatory affairs, quality assurance, contracts, and finance. Activities include participating in both the development of vaccines and adjuvants, assisting in the authoring the Chemistry, Manufacturing and Controls and Toxicology sections of Investigational New Drug submissions, providing protocol and Investigator Brochure review, and assisting in providing oversight of Contract Manufacturing Organizations. - Assist in the evaluation and propose appropriate toxicity studies and models for products intended to be studied as vaccines. - Coordinate with Quality, Regulatory and Technical team members for health regulatory compliance. - Assist the team with impact/risk assessment from issues, failures and deviations during manufacturing and pre-clinical studies. - Develop, coordinate and monitor business agreements to include MTAs, CRADAs, DTAs, and other agreements, as necessary. - Prepare technical reports, updates and summaries for internal meetings with Division Management. - Perform site-visits of CMOs at kick-off or during critical project execution stages or for troubleshooting as requested by the POC. - Maintain an organized, efficient, and accessible electronic document filing system. This includes historical, current and projected information on proposals, presentations, business agreements, grant awards, cGMP projects and other Branch activities. - Review GMP manufacturing batch records, SOPS, deviation reports, etc. - Participate with Team members to track product stability reports with respect to stability timepoints, review the product stability protocol for consistency and completeness, ensure that the stability program matches the requirement per the project Statement of Work, review stability Certificate of Analysis and/or Stability reports/data for out of specification testing results, issue the Shelf-Life Extension document after reviewing of the stability report. - Assist in the preparation and review of regulatory documents including pre-IND materials, and IND, as required. - Prepare oral and written presentations for internal and external programmatic and scientific meetings. - Participate in virtual and on-site audits of vendors. Experience Required / Requirements - MS degree in biochemistry or biology or equivalent and at least 8 years of experience in industry, or BS degree in biochemistry or biology or equivalent education and at least 10 years of experience in industry. - PMP certification and experience in managing cGMP of biologics is preferred. Benefits - 100% Medical, Dental & Vision premium coverage for Employees - Paid Time Off (Including Holidays) - Employee Referral Bonus - 401K Match - Tuition reimbursement and professional development opportunities - Flexible Spending Accounts: - Healthcare (FSA) - Parking Reimbursement Account (PRK) - Dependent Care Assistant Program (DCAP) - Transportation Reimbursement Account (TRN)   The diversity of Axle’s employees is a tremendous asset. We are firmly committed to providing equal opportunity in all aspects of employment and will not tolerate any illegal discrimination or harassment-based age, race, gender, religion, national origin, disability, marital status, covered veteran status, sexual orientation, status with respect to public assistance, and other characteristics protected under state, federal, or local law and to deter those who aid, abet, or induce discrimination or coerce others to discriminate.   Accessibility: If you need an accommodation as part of the employment process please contact:  Email: careers@axleinfo.com   Disclaimer: The above description is meant to illustrate the general nature of work and level of effort being performed by individual’s assigned to this position or job description. This is not restricted as a complete list of all skills, responsibilities, duties, and/or assignments required. Individuals may be required to perform duties outside of their position, job description or responsibilities as needed.
ID
2021-1933
Job Locations US-MD-Rockville
Axle Informatics is a bioinformatics and information technology company that offers innovative computer services, informatics, and enterprise solutions to research centers and healthcare organizations around the globe. With experts in software engineering, bioinformatics and program management, we focus on developing and applying technology tools and techniques to empower decision-making and accelerate the discovery in translational research. We work with some of the top research organizations and facilities in the country including multiple institutes at the National Institutes of health (NIH).
ID
2021-1931
Job Locations US-MD-Rockville
Axle Informatics is a bioinformatics and information technology company that offers innovative computer services, informatics, and enterprise solutions to research centers and healthcare organizations around the globe. With experts in software engineering, bioinformatics and program management, we focus on developing and applying technology tools and techniques to empower decision-making and accelerate the discovery in translational research. We work with some of the top research organizations and facilities in the country including multiple institutes at the National Institutes of health (NIH).
ID
2021-1930
Job Locations US-MD-Rockville
Axle Informatics is a bioinformatics and information technology company that offers innovative computer services, informatics, and enterprise solutions to research centers and healthcare organizations around the globe. With experts in software engineering, bioinformatics and program management, we focus on developing and applying technology tools and techniques to empower decision-making and accelerate the discovery in translational research. We work with some of the top research organizations and facilities in the country including multiple institutes at the National Institutes of health (NIH).
ID
2021-1929
Job Locations US-MD-Bethesda
Axle Informatics is a bioscience and information technology company that offers advancements in translational research, biomedical informatics, and data science applications to research centers and healthcare organizations around the globe. With experts in biomedical science, software engineering, and program management, we focus on developing and applying research tools and techniques to empower decision-making and accelerate research discoveries. We work with some of the top research organizations and facilities in the country including multiple institutes at the National Institutes of Health (NIH).   Overview Axle is seeking a highly ambitious, adaptable, structured, and detail-oriented Biologist to join our vibrant team at the National Institutes of Health (NIH), National Institute of Allergy and Infectious Diseases (NIAID), Vaccine Research Center (VRC), Cellular Immunology Section (CIS), Bethesda, MD Responsibilities - Perform serological assays including ELISA and neutralization assays. - Perform molecular biology techniques including PCR, cloning and qRT-PCR. - Produce and purify proteins using transient transfection of mammalian cells. - Culture and maintain cell lines and primary cell cultures. - Independently and collaboratively plan, develop, and implement experiments and protocols. - Work and communicate with a team of scientists in the Viral Pathogenesis Laboratory. - Train staff and others on the methods and procedures used in the laboratory. - Locate and review literature pertinent to projects and to identify/modify the most applicable protocols and methods for experiments. - Develop methods, collect, organize, and record experimental data suitable for publication. - Correspond with and develop collaborations with other laboratories in developing new methodology and expanding current research projects. - Attend conferences, meetings, and lectures on subjects of relevance to the research program. - Troubleshoot assays and adjust scientific methodology to correct problems or deficiencies in a research project, experiment, or trial. - Maintain accurate laboratory records to ensure proper retention of scientific data. Experience Required / Requirements - Bachelor’s degree in biological sciences is required. - Minimum of two (2) years of experience in biology or a related field. - Demonstrated experience working in a laboratory environment. - Demonstrated knowledge of maintaining accurate and detailed records. - Demonstrated knowledge of proper laboratory disposal methods and safety procedures. Benefits - 100% Medical, Dental & Vision premium coverage for Employees - Paid Time Off (Including Holidays) - Employee Referral Bonus - 401K Match - Tuition reimbursement and professional development opportunities - Flexible Spending Accounts: - Healthcare (FSA) - Parking Reimbursement Account (PRK) - Dependent Care Assistant Program (DCAP) - Transportation Reimbursement Account (TRN)   The diversity of Axle’s employees is a tremendous asset. We are firmly committed to providing equal opportunity in all aspects of employment and will not tolerate any illegal discrimination or harassment-based age, race, gender, religion, national origin, disability, marital status, covered veteran status, sexual orientation, status with respect to public assistance, and other characteristics protected under state, federal, or local law and to deter those who aid, abet, or induce discrimination or coerce others to discriminate.   Accessibility: If you need an accommodation as part of the employment process please contact:  Email: careers@axleinfo.com   Disclaimer: The above description is meant to illustrate the general nature of work and level of effort being performed by individual’s assigned to this position or job description. This is not restricted as a complete list of all skills, responsibilities, duties, and/or assignments required. Individuals may be required to perform duties outside of their position, job description or responsibilities as needed.
ID
2021-1928
Job Locations US-MD-Gaithersburg
Axle Informatics is a bioscience and information technology company that offers advancements in translational research, biomedical informatics, and data science applications to research centers and healthcare organizations around the globe. With experts in biomedical science, software engineering, and program management, we focus on developing and applying research tools and techniques to empower decision-making and accelerate research discoveries. We work with some of the top research organizations and facilities in the country including multiple institutes at the National Institutes of Health (NIH).   Overview Axle is seeking a highly ambitious, adaptable, structured, and detail-oriented Senior Scientist to join our vibrant team at the National Institutes of Health (NIH), National Institute of Allergy and Infectious Diseases (NIAID), Vaccine Research Center (VRC), Vaccine Production Program (VPP), Gaithersburg, MD. Responsibilities - Conduct and participate in projects that are complex and scientifically demanding within a specific area/field. - Initiate, implement, plan, direct, and execute scientific research and development. - Make detailed observations, analyze data, and interpret results. Demonstrate scientific rigor in assessing own data and that of others. - Responsible for contributing to team for meeting project goals within time and budget constraints. - Manage the projects of other scientists or associates. - Independently plan, design, and execute complex projects within a specific scientific field utilizing good scientific judgment by conducting more than one project at a time. - Develop research findings and make recommendations. - Effectively present results at internal meetings and external scientific meetings. - Make recommendations on outside technologies for company to pursue. - Plan, design, and execute projects within a specific scientific field through critical participation in functional unit or project team. - Conduct, plan, and lead one or more highly complex scientific project, including determining objectives and organizing activities. - Work independently within project teams to design, develop and optimize analytical assays and provide assay support for clinical trial candidates. - Lead method development and project support, as well as being involved in project presentations and cutting-edge scientific investigations. - Lead the design and execution of experiments required for the development of analytical assays required for development and clinical manufacturing. Experience Required / Requirements - PhD in biochemist or an immunologist or related discipline. - Minimum of ten (10) years of relevant years of experience and capabilities. - Thorough understanding of protein and process analysis with experience in quantitative and qualitative protein analysis for assay development is required. - Knowledge of the requirements and experience developing, qualifying and/or validating assays for cGMP products and managing method transfers between laboratories is highly desirable. - Prior supervisory experience is required and experience with interdisciplinary teams and matrix management environments is desired. This position involves managing the projects of a team with around 10 contractors. Benefits - 100% Medical, Dental & Vision premium coverage for Employees - Paid Time Off (Including Holidays) - Employee Referral Bonus - 401K Match - Tuition reimbursement and professional development opportunities - Flexible Spending Accounts: - Healthcare (FSA) - Parking Reimbursement Account (PRK) - Dependent Care Assistant Program (DCAP) - Transportation Reimbursement Account (TRN)   The diversity of Axle’s employees is a tremendous asset. We are firmly committed to providing equal opportunity in all aspects of employment and will not tolerate any illegal discrimination or harassment-based age, race, gender, religion, national origin, disability, marital status, covered veteran status, sexual orientation, status with respect to public assistance, and other characteristics protected under state, federal, or local law and to deter those who aid, abet, or induce discrimination or coerce others to discriminate.   Accessibility: If you need an accommodation as part of the employment process please contact:  Email: careers@axleinfo.com   Disclaimer: The above description is meant to illustrate the general nature of work and level of effort being performed by individual’s assigned to this position or job description. This is not restricted as a complete list of all skills, responsibilities, duties, and/or assignments required. Individuals may be required to perform duties outside of their position, job description or responsibilities as needed.
ID
2021-1927
Job Locations US-MD-Frederick
Axle Informatics is a scientific research and information technology company that offers innovative computer services, informatics, and bioresearch solutions to research centers and healthcare organizations around the globe. With experts in software engineering, bioinformatics, molecular research, and program management, we focus on developing and applying technological tools and scientific techniques to empower the world of research. We work with some of the top research organizations and facilities in the country including multiple institutes at the National Institutes of health (NIH), which means candidates will be receiving the best on-the-job training possible in this field.   Axle is currently seeking an experienced scientific data curator to join the Serological Sciences Network Coordinating Center (SSNCC).The SSNCC serves as the coordinating center for the NCI Serological Sciences Network (SeroNet), the nation’s largest coordinated effort to study the immune response to COVID-19. The position is location in Frederick, MD.   Responsibilities: - Curating research data from SeroNet investigations for submission into public data repositories upon manuscript acceptance. - Coordinate the SeroNet data sharing workflow by mentoring SeroNet data submitters in the preparation of their data submission packages.  - Ensuring timely submission of data by SeroNet awardees and the preparation of datasets for submission to the final data sharing portals. - Document data ingestion processes and curation SOPs. - Write data release notes. - Produce data reports. - Develop accurate, thorough, and timely data reports for our stakeholders. Qualifications: - A Doctoral degree, or a Master’s degree with at least 2 years of relevant experience, from an accredited college or university according to the Council for Higher Education Accreditation in Biology, Bioinformatics, Biotechnology, or a similar field. - A deep familiarity with immunology and infectious diseases. - Ability to multi-task and work with minimal supervision. - A thorough understanding of the biological data curation process, including the importance of data provenance, levels of evidence; ontologies and controlled vocabularies used to annotate biological and clinical data. - Experience working with common biomedical data types derived from disease model systems and patients. - Experience submitting data to common public repositories such as dbGaP, SRA and ImmPort - Familiarity with a scripting language (e.g., Perl or Python) is a plus - Experience with biological data management. - Experience working in a laboratory setting. - Excellent oral and written communication skills. - Attention to detail. -   Benefits - 100% Medical, Dental & Vision premium coverage for Employees - Paid Time Off (Including Holidays) - Employee Referral Bonus - 401K Match - Tuition reimbursement and professional development opportunities - Flexible Spending Accounts: - Healthcare (FSA) - Parking Reimbursement Account (PRK) - Dependent Care Assistant Program (DCAP) - Transportation Reimbursement Account (TRN) The diversity of Axle’s employees is a tremendous asset. We are firmly committed to providing equal opportunity in all aspects of employment and will not tolerate any illegal discrimination or harassment based age, race, gender, religion, national origin, disability, marital status, covered veteran status, sexual orientation, status with respect to public assistance, and other characteristics protected under state, federal, or local law and to deter those who aid, abet, or induce discrimination or coerce others to discriminate.      Accessibility: If you need an accommodation as part of the employment process please contact:        Email: careers@axleinfo.com     Disclaimer: The above description is meant to illustrate the general nature of work and level of effort being performed by individual’s assigned to this position or job description. This is not restricted as a complete list of all skills, responsibilities, duties, and/or assignments required. Individuals may be required to perform duties outside of their position, job description or responsibilities as needed.    
ID
2021-1926
Job Locations US-MD-Gaithersburg
Axle Informatics is a bioscience and information technology company that offers advancements in translational research, biomedical informatics, and data science applications to research centers and healthcare organizations around the globe. With experts in biomedical science, software engineering, and program management, we focus on developing and applying research tools and techniques to empower decision-making and accelerate research discoveries. We work with some of the top research organizations and facilities in the country including multiple institutes at the National Institutes of Health (NIH).   Overview Axle is seeking a highly ambitious, adaptable, structured, and detail-oriented Scientist to join our vibrant team at the National Institutes of Health (NIH), National Institute of Allergy and Infectious Diseases (NIAID), Vaccine Research Center (VRC), Vaccine Production Program (VPP), Gaithersburg, MD. Responsibilities - Contribute to the generation of stable cell lines for vaccine and therapeutic protein candidates including monoclonal antibodies, recombinant proteins, and virus-like particles. - Independently execute each step of the cell line development process including plasmid production, transfection, single cell cloning, clone expansion in static culture plates and shake flasks, fed-batch analysis, and clone stability studies. - Use automated platforms for clone selection and screening. - Prepare plasmid DNA using standard molecular cloning techniques. - Participate in cell line development platform design, optimization, and cycle-time reduction studies including methods for clone selection, expansion, ranking, and characterization. - Perform small-scale process development studies using various culture vessels including tissue culture plates, shake flasks, and small-scale bioreactors. - Generate stable pools and perform transient protein production for supply of reagent-grade material. - Provide laboratory support for medium preparation and ordering of supplies. - Maintenance of cell counters and bioprocess analyzers, coordination of service visits, and regular ordering of consumables. - Train other laboratory personnel on use of equipment and corresponding processes. - Write and review technical reports documenting process development studies and stable cell line generation work. - Work with other team members to generate experimental plans for process development studies. - Write and review standard operating procedures for cell line development processes and instrumentation. - Maintain complete documentation records, including a detailed and up-to-date laboratory notebook, to support regulatory filings. - Regularly communicate progress to team lead and present work to cell line development team. Experience Required / Requirements - BS in Biological Sciences with a minimum of 3 years of relevant work experience or MS in Biological Sciences with independent research experience in an academic or industrial setting. - Hands-on experience with aseptic technique and mammalian cell culture along with supporting technologies for cell line engineering including cell counting, high-throughput transfection, single-cell cloning, and flow cytometry. - Experience in preparing technical reports, standard operating procedures, and data presentations. - Ability to work independently to execute defined experiments and troubleshoot issues as needed to meet project timelines. - Ability to effectively communicate plans, results, challenges, and ideas to other team members in oral and written forms. - Familiarity with computer software for word processing and data analysis. - Experience in monoclonal antibody and/or vaccine production. Benefits - 100% Medical, Dental & Vision premium coverage for Employees - Paid Time Off (Including Holidays) - Employee Referral Bonus - 401K Match - Tuition reimbursement and professional development opportunities - Flexible Spending Accounts: - Healthcare (FSA) - Parking Reimbursement Account (PRK) - Dependent Care Assistant Program (DCAP) - Transportation Reimbursement Account (TRN)   The diversity of Axle’s employees is a tremendous asset. We are firmly committed to providing equal opportunity in all aspects of employment and will not tolerate any illegal discrimination or harassment-based age, race, gender, religion, national origin, disability, marital status, covered veteran status, sexual orientation, status with respect to public assistance, and other characteristics protected under state, federal, or local law and to deter those who aid, abet, or induce discrimination or coerce others to discriminate.   Accessibility: If you need an accommodation as part of the employment process please contact:  Email: careers@axleinfo.com   Disclaimer: The above description is meant to illustrate the general nature of work and level of effort being performed by individual’s assigned to this position or job description. This is not restricted as a complete list of all skills, responsibilities, duties, and/or assignments required. Individuals may be required to perform duties outside of their position, job description or responsibilities as needed.
ID
2021-1925
Job Locations US-VA-Tysons
Axle Informatics is a bioinformatics and information technology company that offers innovative computer services, informatics, and enterprise solutions to research centers and healthcare organizations around the globe. With experts in software engineering, bioinformatics and program management, we focus on developing and applying technology tools and techniques to empower decision-making and accelerate the discovery in translational research. We work with some of the top research organizations and facilities in the country.  Overview    Axle is seeking a highly ambitious, adaptable, structured, and detail-oriented BI (Tableau Developer)to join our vibrant team at Tysons, VA.  
ID
2021-1923
Job Locations US-MD-Rockville
Axle Informatics is a bioscience and information technology company that offers advancements in translational research, biomedical informatics, and data science applications to research centers and healthcare organizations around the globe. With experts in biomedical science, software engineering, and program management, we focus on developing and applying research tools and techniques to empower decision-making and accelerate research discoveries. We work with some of the top research organizations and facilities in the country including multiple institutes at the National Institutes of Health (NIH).   Overview Axle is seeking a highly ambitious, adaptable, structured, and detail-oriented Laboratory Technician to join our vibrant team at the National Institutes of Health (NIH), National Institute of Allergy and Infectious Diseases (NIAID), Division of Intramural Research (DIR), Molecular HIV Host Interactions Section (MHHIS), Rockville, MD. Responsibilities - Perform experiments in a biological level II lab involving molecular biology, cell biology, virology, immunology and bioinformatics-related technologies. - Work efficiently in an organized way, including but not limited to experimental design; data collection and recording; troubleshooting; data organization, analysis, and interpretation; uploading sequences to sequencing database. - Prepare reports and present data to supervisors, lab members, and collaborators. Generate protocols and updates. - Cooperate and communicate effectively with supervisors and the research team. Receive supervision/instruction from supervisors and provide timely feedback. - Responsible for sample shipping, receiving, storage, and inventory. Maintain and search sample and data databases. - Perform lab purchasing, receiving, inventory and maintain lab equipment. - Comply with institution’s rules and regulations, such as institutional review board protocols, environmental health and safety, and waste management. Experience Required / Requirements - Bachelor’s degree in Molecular Biology or a related field is required. Master’s degree is a plus. - Minimum of two (2) years of experience working in a molecular biological laboratory is required. - Experience with molecular biological techniques, including but not limited to buffer preparation; DNA/RNA isolation and quantification; primer/probe design; PCR; RT-PCR; qPCR; and gel electrophoresis, imaging and purification. - Experience with sequencing and primary sequence analysis (i.e., BioEdit and/or MEGA). - Familiarity with sequencing databases (e.g., dbGaP, SRA). - Experience with molecular, cellular, viral, and immune assays is a plus, including DNA cloning, western blot, ELISA, flow cytometry, immunochemistry, and viral stock preparation and titration. - Experience with MS Word, Excel, Access, and GraphPad Prism. Experience with Linux programing and cloud computing is a plus. Benefits - 100% Medical, Dental & Vision premium coverage for Employees - Paid Time Off (Including Holidays) - Employee Referral Bonus - 401K Match - Tuition reimbursement and professional development opportunities - Flexible Spending Accounts: - Healthcare (FSA) - Parking Reimbursement Account (PRK) - Dependent Care Assistant Program (DCAP) - Transportation Reimbursement Account (TRN)   The diversity of Axle’s employees is a tremendous asset. We are firmly committed to providing equal opportunity in all aspects of employment and will not tolerate any illegal discrimination or harassment-based age, race, gender, religion, national origin, disability, marital status, covered veteran status, sexual orientation, status with respect to public assistance, and other characteristics protected under state, federal, or local law and to deter those who aid, abet, or induce discrimination or coerce others to discriminate.   Accessibility: If you need an accommodation as part of the employment process please contact:  Email: careers@axleinfo.com   Disclaimer: The above description is meant to illustrate the general nature of work and level of effort being performed by individual’s assigned to this position or job description. This is not restricted as a complete list of all skills, responsibilities, duties, and/or assignments required. Individuals may be required to perform duties outside of their position, job description or responsibilities as needed.
ID
2021-1922
Job Locations US-MD-Rockville
Axle Informatics is a bioscience and information technology company that offers advancements in translational research, biomedical informatics, and data science applications to research centers and healthcare organizations around the globe. With experts in biomedical science, software engineering, and program management, we focus on developing and applying research tools and techniques to empower decision-making and accelerate research discoveries. We work with some of the top research organizations and facilities in the country including multiple institutes at the National Institutes of Health (NIH).   Overview Axle is seeking a highly ambitious, adaptable, structured, and detail-oriented Communications Specialist to join our vibrant team at the National Institutes of Health (NIH), National Institute of Allergy and Infectious Diseases (NIAID), Office of the Director (OD), Office of Science Management and Operations (OSMO), Office of Workplace Solutions (OWS), Conference Services and Events Management Branch (CSEMB), Rockville, MD. Responsibilities - Research, develop, design, and implement communications projects and tasks using appropriate vehicles for communicating information about the Office of Workplace Solutions (OWS) and its programs. - Work with Senior Leadership to design effective communication strategies. - Independently design and carry out a variety of projects and communications strategies to enhance the dissemination of information and increase the NIAID employees’ understanding of the OWS mission, services, and accomplishments of the Office. - Monitor internal and external communications feedback and adjust communications plans accordingly. - Ensure all communication pieces are consistent and adhere to OWS branding, image, and graphics requirements. - Create or provide updates on PowerPoint presentations. - Oversee the development, edit, and add content to the OWS website and splash page. - Develop relationships and partnerships necessary to ensure effective communication about OWS's activities and values. - Establish and maintain effective working relationships with OWS and the Office of Communications and Government Relations (OCGR) personnel. - Organize outreach events necessary to effectively raise awareness of OWS’s mission and services. - Establish rapport with continuously changing stakeholders. - Identify and conceptualize ideas and materials needed to ensure that website, articles, and messages regarding OWS’s objectives and initiatives are conveyed to interested parties. - Review and edit where necessary the organization, length, and tone of written and oral content; edit documents to improve clarity, formatting, and grammar; and assist with design and graphics. - Develop and execute strategies and processes to expand and refresh communications products for dissemination through all feasible means of electronic communications. - Evaluate the success of OWS’s communication activities and advise OWS’s leadership on how to improve the effectiveness of its communicative efforts. - Utilize contemporary communication, content development, and content distribution computer technologies and techniques to produce measurably successful communication outcomes. - Acquire and/or maintain detailed knowledge of internal policies, principles, and strategies, and keep up to date with relevant developments. - Write and edit external and internal communication materials, articles, presentations, talking points, and white papers. - Develop, gather, edit, and assemble content for the creation of a quarterly Workplace Connect (WPC) newsletter. - Layout content, create pdfs, and distribute the WPC newsletter. - Create and update external and internal website content and assist in the development of engaging videos, webinars, podcasts, and other platforms to effectively communicate OWS’s mission and services. - Assess, compile, and format actionable metrics pertaining to the effectiveness of communications outreach. - Conduct market research and monitor trends in delivering communications. - Lead special projects as assigned. - Manage the workflow of communications campaigns and projects to ensure timely production and delivery. - Develop and maintain internal communications processes and SOPs. - Participate in meetings, workshops, trainings, and seminars to enhance knowledge and/or gather information for communications tasks or projects. - Facilitate meetings with OWS staff and stakeholders. - Present information on a variety of topics to appropriate OWS staff and/or stakeholders to keep them informed on communications campaigns and efforts. Experience Required / Requirements - Bachelor’s degree in communications, Journalism, Public Relations, or a related field is required. - Minimum of 2 years of experience in communications strategy development is required. - Intermediate knowledge of MS Excel. - Advanced knowledge of MS Word and PowerPoint. - Strong communication skills, both oral and written. - Ability to perform substantive and copy editing of documents. - Analytic, organizational, and time management skills. - Ability to work independently and in a collaborative team environment consisting of a diverse population. - Expert knowledge of data collection, in-depth analysis, interpretation to report research and program evaluation results concisely to a wide variety of audiences. - Expert oral and written communication skills to convey complex information on outreach effectiveness to advise top-level management. - Experience with web content and materials development, including principles of web design (essential). Benefits - 100% Medical, Dental & Vision premium coverage for Employees - Paid Time Off (Including Holidays) - Employee Referral Bonus - 401K Match - Tuition reimbursement and professional development opportunities - Flexible Spending Accounts: - Healthcare (FSA) - Parking Reimbursement Account (PRK) - Dependent Care Assistant Program (DCAP) - Transportation Reimbursement Account (TRN)   The diversity of Axle’s employees is a tremendous asset. We are firmly committed to providing equal opportunity in all aspects of employment and will not tolerate any illegal discrimination or harassment-based age, race, gender, religion, national origin, disability, marital status, covered veteran status, sexual orientation, status with respect to public assistance, and other characteristics protected under state, federal, or local law and to deter those who aid, abet, or induce discrimination or coerce others to discriminate.   Accessibility: If you need an accommodation as part of the employment process please contact:  Email: careers@axleinfo.com   Disclaimer: The above description is meant to illustrate the general nature of work and level of effort being performed by individual’s assigned to this position or job description. This is not restricted as a complete list of all skills, responsibilities, duties, and/or assignments required. Individuals may be required to perform duties outside of their position, job description or responsibilities as needed.
ID
2021-1921
Job Locations US
Axle Informatics is a bioinformatics and information technology company that offers innovative computer services, informatics, and enterprise solutions to research centers and healthcare organizations around the globe. With experts in software engineering, bioinformatics and program management, we focus on developing and applying technology tools and techniques to empower decision-making and accelerate the discovery in translational research. We work with some of the top research organizations and facilities in the country including multiple institutes at the National Institutes of health (NIH) / HRSA. Job Description We are looking for DevOps or Application Reliability Engineer trainees to support portions of Projects that Axle Informatics teams are working on currently at NIH. These positions will focus on translation and implementation of code in a novel, scalable, cloud based, image analysis platform. Additionally, for qualified candidates projects involving building novel, scalable, interactive graphics for viewing and analyzing “big” data will be available.   Responsibilities: - Attain hands-on experience with developing CI/CD pipelines with Jenkins and managing Cloud infrastructure such as AWS, GCP. - Manage docker containers using docker-compose and create docker images using Dockerfiles. - Assist in development of software using a variety of languages (ex: Shell, Terraform, Python, etc.). - Design new architecture and performance enhancements for existing systems. - Participate in testing and fixing bugs in each release cycle. - Gaining on-site work experience at various locations within the NIH. Who should apply: - Anyone who has an interest and understanding in computer science, and/or reliable software architecture - Students who enjoy creating novel solutions to complex problems. - Students who have experience coding in Shell, Terraform, or python. - Experience with Ubuntu, Red Hat Enterprise Linux or CentOS and good understanding on Linux concepts such as iptables, DNS, networking configuration. - Good deep understanding of various phases of the Software Development Life Cycle. - Those who are hungry to learn. We will give you data, tools and resources and let you soar! - Those who want to apply what they’re learning in school to concrete real world problems. - Those who aim to simplify their work processes by finding patterns and making work more efficient - Those who care about the quality of their work and are adamant in persisting until a job is complete - Those who have a strong work ethic and coolness under pressure in a “live” environment Skills we’d love for you to have (but not required): - Optimization of others code to improve efficiency/speed of execution. - Familiar with containerization tools such as docker and docker-compose. - Basic knowledge of MySQL and SQL, Linux, Apache or any other object-oriented designs. - Understanding of AngularJS, Node.js and Bootstrap within a dynamic content environment - Ability to learn quickly and multitask in a fast-paced environment. Extreme attention to detail. Requirements: - Junior or senior BA/BS or working towards an MS, Post baccalaureate or PhD candidate in Computer Science, computer engineering, electricals engineering, or a related - Able to work independently at times and be able to give 40 hours/week. - Ability to work under independently, just as well as general supervision. - The ability to work in a team environment with changing priorities.   The diversity of Axle’s employees is a tremendous asset. We are firmly committed to providing equal opportunity in all aspects of employment and will not tolerate any illegal discrimination or harassment based age, race, gender, religion, national origin, disability, marital status, covered veteran status, sexual orientation, status with respect to public assistance, and other characteristics protected under state, federal, or local law and to deter those who aid, abet, or induce discrimination or coerce others to discriminate.    Accessibility: If you need an accommodation as part of the employment process please contact:  Email: careers@axleinfo.com   Disclaimer:The above description is meant to illustrate the general nature of work and level of effort being performed by individual’s assigned to this position or job description. This is not restricted as a complete list of all skills, responsibilities, duties, and/or assignments required. Individuals may be required to perform duties outside of their position, job description or responsibilities as needed.
ID
2021-1920
Job Locations US-MD-Rockville
Axle Informatics is a bioinformatics and information technology company that offers innovative computer services, informatics, and enterprise solutions to research centers and healthcare organizations around the globe. With experts in software engineering, bioinformatics and program management, we focus on developing and applying technology tools and techniques to empower decision-making and accelerate the discovery in translational research. We work with some of the top research organizations and facilities in the country including multiple institutes at the National Institutes of health (NIH).   Axle Informatics is seeking a Senior Digital Process Automation Advisor to deliver highly relevenant advise and direction to our clients for the business process needs.
ID
2021-1919
Job Locations US-MD-Bethesda
Axle Informatics is a bioscience and information technology company that offers advancements in translational research, biomedical informatics, and data science applications to research centers and healthcare organizations around the globe. With experts in biomedical science, software engineering, and program management, we focus on developing and applying research tools and techniques to empower decision-making and accelerate research discoveries. We work with some of the top research organizations and facilities in the country including multiple institutes at the National Institutes of Health (NIH).   Overview Axle is seeking a highly ambitious, adaptable, structured, and detail-oriented Scientist to join our vibrant team at the National Institutes of Health (NIH), National Institute of Allergy and Infectious Diseases (NIAID), Division of Intramural Research (DIR), Laboratory of Viral Diseases (LVD), DNA tumor Virus Section, Bethesda, MD. Note: Part-time position for a total of 60 hours. Responsibilities - Search online sequence databases and publications for sequences of novel papillomavirus complete genomes that have been deposited since last PaVE update. - Compare L1 nucleotide sequence of novel PV genomes to determine (using ICTV rules) whether they are novel viral types and to assign Genus and Species. - Download the existing PV genomes from the PaVE website and combine with the new genomes. - Annotate the combined novel and existing genomes using the PuMA- papillomavirus genome annotation tool located at https://github.com/KVD-lab/puma. Generate output of annotated genome, protein and region sequences for uploading into PaVE. - Prepare tables of final Human and Animal PV genomes. - Run a phylogenetic analysis to generate a Newick phylogenetic tree for upload to the PaVE website. - During the update process, consult with members of NIAID Bioinformatics Computational Biosciences Branch (BCBB) team to troubleshoot any issues that arise. Experience Required / Requirements - PhD in a related field is required. - Detailed knowledge of the Papillomavirus genome taxonomy, phylogeny and annotation is required. Benefits - 100% Medical, Dental & Vision premium coverage for Employees - Paid Time Off (Including Holidays) - Employee Referral Bonus - 401K Match - Tuition reimbursement and professional development opportunities - Flexible Spending Accounts: - Healthcare (FSA) - Parking Reimbursement Account (PRK) - Dependent Care Assistant Program (DCAP) - Transportation Reimbursement Account (TRN)   The diversity of Axle’s employees is a tremendous asset. We are firmly committed to providing equal opportunity in all aspects of employment and will not tolerate any illegal discrimination or harassment-based age, race, gender, religion, national origin, disability, marital status, covered veteran status, sexual orientation, status with respect to public assistance, and other characteristics protected under state, federal, or local law and to deter those who aid, abet, or induce discrimination or coerce others to discriminate.   Accessibility: If you need an accommodation as part of the employment process please contact:  Email: careers@axleinfo.com   Disclaimer: The above description is meant to illustrate the general nature of work and level of effort being performed by individual’s assigned to this position or job description. This is not restricted as a complete list of all skills, responsibilities, duties, and/or assignments required. Individuals may be required to perform duties outside of their position, job description or responsibilities as needed.
ID
2021-1918
Job Locations US-VA-Tysons
Axle Informatics is a bioinformatics and information technology company that offers innovative computer services, informatics, and enterprise solutions to research centers and healthcare organizations around the globe. With experts in software engineering, bioinformatics and program management, we focus on developing and applying technology tools and techniques to empower decision-making and accelerate the discovery in translational research. We work with some of the top research organizations and facilities in the country  Overview Axle is seeking a highly ambitious, adaptable, structured, and detail oriented (.NET Developer) to join our vibrant team at (Tysons Corner,VA). Responsibilities - Build high-quality, scalable, and predictable end-to-end web applications on Microsoft technology stack and maintain them.   - Ability to develop fluently using ASP.NET, .Net Core, C#, Web API, MVC, MVP, SQL Server, jQuery, JavaScript, JSON, entity framework.  - Develop code within the Azure Cloud, Windows/SQL Server, Application Support and PowerShell scripting,  - Experience using TFS, visual studio IDE, and GIT repository.  - Experience in Product Life Cycle Management, agile methodologies: Scrum, Kanban, etc.  - Collaborate with internal teams to produce software design and architecture.  - Develop documentation throughout the software development life cycle (SDLC)  - Experience in resolving application performance issues by analyzing the root cause, impact analysis, and applying unit-tested code fix.  - Make regular modifications to existing software for error correction, adaptation to new software, and to improve overall function and performance.  - Improve web application design by employing the industry's most relevant best practices and SOLID design principle. Qualification   - Candidate should be in the United States for a minimum of 3 years.  - Final candidates will go through HHS public trust background check and should be clearable. - US Citizen or Green Card Holders only - Minimum 4+ experience of .net experience - Experience in ASP.NET Development, C#, MVP, MVC, .net core.  - JavaScript and AngulaJ frameworks   - Object-oriented and enterprise architecture design patterns  - Demonstrated experience designing, developing and maintain applications within Azure/ cloud computing services.  - Advanced problem-solving and troubleshooting skills.  - Operations support experience required.  - Experience in MS SQL Server database development   - Experience designing and implementing web services.   - Experience with AngularJS, Bootstrap, HTML5, and CSS  - Microsoft certifications in MVC .Net preferred.  - Thinks independently and demonstrates exceptional written and oral communications skills  Benefits 100% Medical, Dental & Vision premium coverage for Employees Paid Time Off (Including Holidays) Employee Referral Bonus 401K Match Tuition reimbursement and professional development opportunities Flexible Spending Accounts: - - Healthcare (FSA) - Parking Reimbursement Account (PRK) - Dependent Care Assistant Program (DCAP) - Transportation Reimbursement Account (TRN)   The diversity of Axle’s employees is a tremendous asset. We are firmly committed to providing equal opportunity in all aspects of employment and will not tolerate any illegal discrimination or harassment based age, race, gender, religion, national origin, disability, marital status, covered veteran status, sexual orientation, status with respect to public assistance, and other characteristics protected under state, federal, or local law and to deter those who aid, abet, or induce discrimination or coerce others to discriminate.      Accessibility: If you need an accommodation as part of the employment process please contact:        Email: careers@axleinfo.com     Disclaimer: The above description is meant to illustrate the general nature of work and level of effort being performed by individual’s assigned to this position or job description. This is not restricted as a complete list of all skills, responsibilities, duties, and/or assignments required. Individuals may be required to perform duties outside of their position, job description or responsibilities as needed.    
ID
2021-1917
Job Locations US-MD-Rockville
Axle Informatics is a bioinformatics and information technology company that offers innovative computer services, informatics, and enterprise solutions to research centers and healthcare organizations around the globe. With experts in software engineering, bioinformatics and program management, we focus on developing and applying technology tools and techniques to empower decision-making and accelerate the discovery in translational research. We work with some of the top research organizations and facilities in the country including multiple agencies at the US Department of Health and Human Services.    Job Description    Axle is seeking a highly ambitious, adaptable, structured, and detail oriented Security Engineer to join our vibrant team at Tysons Corner, VA.   Responsibilities  - Responsible for maintaining & enhancing information security management program(s) to ensure integrity, confidentiality, and availability of information. - Provide guidance and best practice recommendations for IT security policies, procedures, and standards that meet regulatory requirements. - Assess and recommend process improvements to ensure all operational and application system changes undergo security impact assessment. - Develop and maintain system security plans, contingency plans, preparing Authority-to-Operate/MOU packages. - Generate security reports related to incidents, vulnerabilities, and configurations. Serve as project manager/lead within IT security projects. - Maintain knowledge of security regulations, best practices, countermeasures, compliance standards, and current threats. - Experience with Penetration Testing and Vulnerability Scanning - Working knowledge of static code analysis and vulnerability assessment tools such as Fortify Static Code Analyzer, Fortify Web inspect, Nessus, Netsparker, Black duck, Coverity, etc. - Experience in determining system risks, threats and implementing and monitoring controls to mitigate defined risks - Knowledge of SecDevOps a plus  Experience Required / Requirements  - Minimum of 4-6 years’ experience in Information Security is required - Excellent communication skills. Must be able to handle client meetings and cater to their security needs. - Strong interpersonal skills and the ability to work as part of a team. - Proficient in reporting and answering analytical questions using vulnerability data - Must demonstrate experience with implementing NIST and Federal Security standards on-premise and cloud environments. - Must be familiar with security tools such as Netsparker, HP Fortify, Splunk, Windows/Linux environments, and application patching for vulnerabilities. Industry-relevant security certifications are desired. Benefits  - 100% Medical, Dental & Vision premium coverage for Employees   - Paid Time Off (Including Holidays)  - Employee Referral Bonus   - 401K Match  - Tuition reimbursement and professional development opportunities  - Flexible Spending Accounts: - Healthcare (FSA) - Parking Reimbursement Account (PRK) - Dependent Care Assistant Program (DCAP) - Transportation Reimbursement Account (TRN)   The diversity of Axle’s employees is a tremendous asset. We are firmly committed to providing equal opportunity in all aspects of employment and will not tolerate any illegal discrimination or harassment based age, race, gender, religion, national origin, disability, marital status, covered veteran status, sexual orientation, status with respect to public assistance, and other characteristics protected under state, federal, or local law and to deter those who aid, abet, or induce discrimination or coerce others to discriminate.   Accessibility: If you need an accommodation as part of the employment process please contact: Email: careers@axleinfo.com   Disclaimer: The above description is meant to illustrate the general nature of work and level of effort being performed by individual’s assigned to this position or job description. This is not restricted as a complete list of all skills, responsibilities, duties, and/or assignments required. Individuals may be required to perform duties outside of their position, job description or responsibilities as needed.
ID
2021-1916
Job Locations US-MD-Rockville
Axle Informatics is a bioscience and information technology company that offers advancements in translational research, biomedical informatics, and data science applications to research centers and healthcare organizations around the globe. With experts in biomedical science, software engineering, and program management, we focus on developing and applying research tools and techniques to empower decision-making and accelerate research discoveries. We work with some of the top research organizations and facilities in the country including multiple institutes at the National Institutes of Health (NIH).   Overview Axle is seeking a highly ambitious, adaptable, structured, and detail-oriented Scientific Program Manager/Clinical Data Manager to join our vibrant team at the National Institutes of Health (NIH), National Institute of Allergy and Infectious Diseases (NIAID), Division of Allergy, Immunology, and Transplantation (DAIT), Clinical Research Operations Program (CROP), Rockville, MD. Responsibilities - Act as subject matter expert (SME) for all data management activities including proper data entry and tracking, human subject’s protection, data confidentiality and related IT security. - Develop and maintain a proficiency in accessing and reviewing clinical study related information from databases used by DAIT and/or NIAID and additional relevant clinical data databases including those of DAIT’s clinical research organization (CRO) awardees, ImmPORT and ClinicalTrials.gov. - Provide expertise to sponsor clinical data management projects on multiple complex studies and programs, both internal and performed by supporting clinical research organizations (CROs). - Provide technical oversight of CROs performing core data management functions including case report form (CRF)/edit check development, user acceptance testing, data cleaning, listings review, and database lock procedures. - Responsible for the oversight of clinical data management study deliverables, evaluating and mitigating data management risks. - Provide expertise to assist in CRF and database design. - Assist in the development and implementation of data transfer and migration plans relating to transitions between CROs. - Perform or oversee development of clinical data management validation plans, data transfer requirements and agreements, and data management plans. - Provide expertise in support of developing sponsor data management SOPs, procedures, PWIs, Plans, Guidance and other quality-related documentation. - Devise and oversee implementation of quality assessment procedures according to data management plans and other means. - Assess the quality of the statistical programming processes through techniques including, but not limited to, good documentation code review and testing. - Assist with the creation and review of CAPAs related to clinical data management. - Review and process clinical trial data to ensure data quality for data analysis. - Participate in clinical study data reviews and other activities related to database lock. - Participate in multi-party clinical data process development initiatives. - Assist in the development of data pathways and system interconnection arrangements. - Provide input on clinical data management system enhancements including design, review, performing user acceptance testing and validation supporting activities. Experience Required / Requirements - Master’s degree in a related discipline required. A PhD in a related discipline is a plus. - At least five (5) years of clinical data management experience is required. - Excellent verbal and strong written communication skills are required as this person is expected to interact with team members from various disciplines every day. - Excellent analytical, organizational and time management skills required. - Thorough understanding and experience with GCP/GxP, Privacy Act and quality requirements are required. - Working knowledge of clinical data management tools is required. - Experience programming and using Medidata Rave, Oracle Argus and RedCap preferred. - Familiarity with clinical trial data standards such as CDISC preferred. - Experience in developing eCRFs and clinical databases required. - Experience creating and evaluating clinical data management plans and agreements preferred. - Experience working within a quality-driven environment is preferred. - Experience creating and evaluating SOPs and CAPAs required. - Systems validation experience preferred. - Knowledge of data systems architecture and structure of data systems is required. - Pharmaceutical industry experience is a plus. - Excellent computer skills, proficient in Microsoft Office, SQL and XML required. - Experience with statistical software such as R, SAS, Stata, & SPS preferred. Benefits - 100% Medical, Dental & Vision premium coverage for Employees - Paid Time Off (Including Holidays) - Employee Referral Bonus - 401K Match - Tuition reimbursement and professional development opportunities - Flexible Spending Accounts: - Healthcare (FSA) - Parking Reimbursement Account (PRK) - Dependent Care Assistant Program (DCAP) - Transportation Reimbursement Account (TRN)   The diversity of Axle’s employees is a tremendous asset. We are firmly committed to providing equal opportunity in all aspects of employment and will not tolerate any illegal discrimination or harassment-based age, race, gender, religion, national origin, disability, marital status, covered veteran status, sexual orientation, status with respect to public assistance, and other characteristics protected under state, federal, or local law and to deter those who aid, abet, or induce discrimination or coerce others to discriminate.   Accessibility: If you need an accommodation as part of the employment process please contact:  Email: careers@axleinfo.com   Disclaimer: The above description is meant to illustrate the general nature of work and level of effort being performed by individual’s assigned to this position or job description. This is not restricted as a complete list of all skills, responsibilities, duties, and/or assignments required. Individuals may be required to perform duties outside of their position, job description or responsibilities as needed.
ID
2021-1914
Job Locations US-MD-Rockville
Axle Informatics is a bioinformatics and information technology company that offers innovative computer services, informatics, and enterprise solutions to research centers and healthcare organizations around the globe. With experts in software engineering, bioinformatics and program management, we focus on developing and applying technology tools and techniques to empower decision-making and accelerate the discovery in translational research. We work with some of the top research organizations and facilities in the country including multiple institutes at the National Institutes of health (NIH).   Axle is seeking an Application Developer ffor the development and management of a knowledge graph database that supports the Genetic and Rare Diseases (GARD) information center, and to support National Center for Translational Sciences (NCATS) Office of Rare Diseases Research (ORDR)’s rare diseases informatics initiatives.   The National Institutes of Health (NIH) is the Nation’s leading medical research agency and the primary federal agency whose mission is to seek fundamental knowledge about the nature and behavior of living systems and the application of that knowledge to enhance health, lengthen life, and reduce illness and disability by supporting and making medical discoveries. NCATS is the only center at the NIH that focuses exclusively on all aspects of the translation of research with an innovative pipeline of treatment discoveries for all diseases. NCATS brings together a diverse group of scientists, including medicinal chemists, biologists, toxicologists, clinicians, and engineers to translate basic science conducted elsewhere into products and services that help improve people’s health and lives. NCATS’ mission is to improve health through smarter science that results in better treatments faster for all diseases, rare or common. Within that remit, the NCATS ORDR’s mission is to advance rare disease research to benefit patients.   Currently, there are about 7,000-10,000 known rare diseases that affect people in the US, yet only a few hundred (less than 5%) have a treatment and even fewer a cure.  A rare disease is defined in US law (Orphan Drug Act (ODA) of 1983,[1] Rare Diseases Act (RDA) of 2002[2]) as a disease or condition that affects fewer than 200,000 people in the US. Most rare diseases affect far fewer patients than this, with most rare diseases affecting only a few hundreds to thousands of patients. Collectively, however, rare diseases are not rare at all, and in total are estimated to affect as many as 25-30 million patients in the US, making rare diseases a large public health consideration.    The ORDR’s GARD information center was established in 2003 under a Congressional Mandate (RDA 2002), and is a federally funded program that has an essential role in the dissemination of public health information to rare disease researchers, clinicians, and patients that is freely accessible to the public.  However, obtaining accurate, comprehensive, timely, and objective information on rare diseases is often difficult, given the large number of rare diseases, rapidly evolving science (especially related to genomics), diverse data sources, and inconsistent nomenclature and ontologies for rare disease classification, among other issues. Recently, GARD has been undergoing a re-envisioning and re-design based on a Neo4j knowledge graph database that integrates rare disease data from multiple sources to keep the information on ~6,000 different rare diseases in GARD up-to-date and useful to the patient and clinical research communities. Research tools, artificial intelligent models, data visualization and informatics infrastructure based on the knowledge graph database will be developed to support rare diseases research and clinical activities, and to answer rare disease research questions likely to inform rare disease research prioritization.    [1] Orphan Drug Act of 1983, amended for prevalence 1984. Pub.L. 97-414 [2] Rare Diseases Act of 2002, Pub.L. 107-280
ID
2021-1913
Job Locations US-MD-Rockville
Axle Informatics is a bioinformatics and information technology company that offers innovative computer services, informatics, and enterprise solutions to research centers and healthcare organizations around the globe. With experts in software engineering, bioinformatics and program management, we focus on developing and applying technology tools and techniques to empower decision-making and accelerate the discovery in translational research. We work with some of the top research organizations and facilities in the country including multiple institutes at the National Institutes of health (NIH).   Axle is seeking a Data Scientist for the development of informatics infrastructure that supports the Genetic and Rare Diseases (GARD) information center and development of data models to support National Center for Translational Sciences (NCATS) Office of Rare Diseases Research (ORDR)’s rare diseases informatics initiatives.   The National Institutes of Health (NIH) is the Nation’s leading medical research agency and the primary federal agency whose mission is to seek fundamental knowledge about the nature and behavior of living systems and the application of that knowledge to enhance health, lengthen life, and reduce illness and disability by supporting and making medical discoveries. NCATS is the only center at the NIH that focuses exclusively on all aspects of the translation of research with an innovative pipeline of treatment discoveries for all diseases. NCATS brings together a diverse group of scientists, including medicinal chemists, biologists, toxicologists, clinicians, and engineers to translate basic science conducted elsewhere into products and services that help improve people’s health and lives. NCATS’ mission is to improve health through smarter science that results in better treatments faster for all diseases, rare or common. Within that remit, the NCATS ORDR’s mission is to advance rare disease research to benefit patients.   Currently, there are about 7,000-10,000 known rare diseases that affect people in the US, yet only a few hundred (less than 5%) have a treatment and even fewer a cure.  A rare disease is defined in US law (Orphan Drug Act (ODA) of 1983,[1] Rare Diseases Act (RDA) of 2002[2]) as a disease or condition that affects fewer than 200,000 people in the US. Most rare diseases affect far fewer patients than this, with most rare diseases affecting only a few hundreds to thousands of patients. Collectively, however, rare diseases are not rare at all, and in total are estimated to affect as many as 25-30 million patients in the US, making rare diseases a large public health consideration.    The ORDR’s GARD information center was established in 2003 under a Congressional Mandate (RDA 2002), and is a federally funded program that has an essential role in the dissemination of public health information to rare disease researchers, clinicians, and patients that is freely accessible to the public.  However, obtaining accurate, comprehensive, timely, and objective information on rare diseases is often difficult, given the large number of rare diseases, rapidly evolving science (especially related to genomics), diverse data sources, and inconsistent nomenclature and ontologies for rare disease classification, among other issues. Recently, GARD has been undergoing a re-envisioning and re-design based on a Neo4j knowledge graph database that integrates rare disease data from multiple sources to keep the information on ~6,000 different rare diseases in GARD up-to-date and useful to the patient and clinical research communities. Research tools, artificial intelligent models, data visualization and informatics infrastructure based on the knowledge graph database will be developed to support rare diseases research and clinical activities, and to answer rare disease research questions likely to inform rare disease research prioritization.    [1] Orphan Drug Act of 1983, amended for prevalence 1984. Pub.L. 97-414 [2] Rare Diseases Act of 2002, Pub.L. 107-280
ID
2021-1912
Job Locations US-MD-Rockville
Axle Informatics is a bioinformatics and information technology company that offers innovative computer services, informatics, and enterprise solutions to research centers and healthcare organizations around the globe. With experts in software engineering, bioinformatics and program management, we focus on developing and applying technology tools and techniques to empower decision-making and accelerate the discovery in translational research. We work with some of the top research organizations and facilities in the country including multiple institutes at the National Institutes of health (NIH).   We are looking for a Full-Stack Developer with a background in computational clusters and high-performance computing (HPC) to build an API framework. You will be working on an interdisciplinary team of developers, DevOps engineers, data scientists, and machine learning researchers. Your primary focus will be to develop a framework to enable data scientists to execute arbitrary analysis code at scale on any number of different computational backends, using a standard set of abstracted APIs and associated user interfaces.
ID
2021-1911