Axle is a bioscience and information technology company that offers advancements in translational research, biomedical informatics, and data science applications to research centers and healthcare organizations nationally and abroad. With experts in biomedical science, software engineering, and program management, we focus on developing and applying research tools and techniques to empower decision-making and accelerate research discoveries. We work with some of the top research organizations and facilities in the country including multiple institutes at the National Institutes of Health (NIH). Axle is seeking a highly ambitious, adaptable, structured, and detail-oriented Bioinformatics Scientist to join our vibrant team at the National Institutes of Health (NIH), National Institute of Allergy and Infectious Diseases (NIAID). Benefits We Offer: - 100% Medical, Dental & Vision Coverage for Employees - Paid Time Off and Paid Holidays - 401K match up to 5% - Educational Benefits for Career Growth - Employee Referral Bonus - Flexible Spending Accounts: - Healthcare (FSA) - Parking Reimbursement Account (PRK) - Dependent Care Assistant Program (DCAP) - Transportation Reimbursement Account (TRN) Responsibilities: - Provide programming and troubleshooting support to the RTB in the dissemination of research data. - Perform computational data analysis and data management. - Work with staff on experimental design, workflow development, programming, data analysis, and composition of manuscripts. - Provide general computational and statistical support/analysis on research data. - Address bioinformatics, scientific computing, and data analysis needs of users within the Division of Intramural Research (DIR) by lending expertise in the proper statistical design of biological experiments involving high-throughput technologies, data mining and knowledge discovery techniques, and data workflow applications development as well as performing omic (genomic/NGS, proteomic, etc.) data analysis for research activities and providing statistical and scientific consultancy for omic experimental design, data collection, and platform considerations. - Provide bioinformatics support to include but not limited to: - omic data analysis, primarily resulting from NGS data analysis (whole-exome, whole-genome, RNA-seq, ChIP-Seq, Single Cell, etc.) - Statistical modeling - Scripting and biological interpretation - Clinical data curation and integration - Scripting for data transformation, QC, and preprocessing high-dimensional research data analysis and interpretation research and clinical data integration, management, transformation, and automation complex data transformation scripting, clinical data curation and medical informatics in support of large scale clinical and omic research initiatives. - Assist with expanding on a scalable and flexible resource to provide NGS bioinformatics, structural biological and computational, machine learning data support to NIAID scientists and investigators. Requirements: - Master's degree; at least 3 years of experience directly related to the duties and responsibilities specified. - Knowledge of scientific approach and methodologies. - Knowledge and understanding of the principles, concepts, methods, and standards of statistical research. - Ability to apply a range of advanced statistical techniques in support of scientific research studies and/or experiments. - Ability to process computer data and to format and generate reports. - Ability to consult with scientific investigators, interpret research requirements, and determine statistical analysis strategies. - Ability to plan, create, program, and manage complex statistical computer databases. - Ability to analyze, interpret, and draw conclusions from complex statistical information. - Knowledge of current and emerging trends in advanced statistical analysis for scientific application. - Knowledge of R programming and/or other statistical software. - Knowledge of scientific reporting and manuscript preparation requirements and standards. - Ability to work in a team environment to design, analyze, and report on research projects. - Strong analytical communication, critical thinking, and problem-solving skills. - In-depth knowledge and understanding of probability and medical statistics theory. - Strong focus and quality and timely delivery of work. - Expertise with Microsoft office (Word, Excel, etc.) - Experience working in a laboratory or clinical setting is a plus. - Ability to obtain and maintain a Public Trust Security clearance. Disclaimer:The above description is meant to illustrate the general nature of work and level of effort being performed by individuals assigned to this position or job description. This is not restricted as a complete list of all skills, responsibilities, duties, and/or assignments required. Individuals may be required to perform duties outside of their position, job description or responsibilities as needed. The diversity of Axle’s employees is a tremendous asset. We are firmly committed to providing equal opportunity in all aspects of employment and will not tolerate any illegal discrimination or harassment based on age, race, gender, religion, national origin, disability, marital status, covered veteran status, sexual orientation, status with respect to public assistance, and other characteristics protected under state, federal, or local law and to deter those who aid, abet, or induce discrimination or coerce others to discriminate. Accessibility: If you need an accommodation as part of the employment process please contact: careers@axleinfo.com

Axle Informatics is a bioscience and information technology company that offers advancements in translational research, biomedical informatics, and data science applications to research centers and healthcare organizations around the globe. With experts in biomedical science, software engineering, and program management, we focus on developing and applying research tools and techniques to empower decision-making and accelerate research discoveries. We work with some of the top research organizations and facilities in the country including multiple institutes at the National Institutes of Health (NIH).   Overview Axle is seeking a highly ambitious, adaptable, structured, and detail-orientedScientist   to join our vibrant team at the National Institutes of Health (NIH), National Institute of Allergy and Infectious Diseases (NIAID),Vaccine Research Center (VRC),Vaccine Production Program  (VPP).   Responsibilities - Conduct and participate in projects that are complex and scientifically demanding within a specific area/field: HPLC, electrophoresis, bio separation techniques to vaccine projects. - Initiate, implement, plan, direct, and execute scientific research and development. - Make detailed observations, analyze data, and interpret results. Demonstrate scientific rigor in assessing own data and that of others. - Effectively present results at internal meetings. - Responsible for meeting project goals within time and budget constraints, including vaccine projects, but not limited to vaccines. - Demonstrate ability for scientific insight and conceptual thinking. Specifically, should be able to clearly define problem statement and make scientific hypothesis. - Independently plan, design, and execute projects within a specific scientific field (bio-separation technology) utilizing good scientific judgment. - Typically conduct more than one vaccine project at a time. - Develop research findings and makes recommendations. - Utilizes forward-looking perspective to contribute to “go/no go” decisions. - Make recommendations on outside technologies for company to pursue.   Experience Required / Requirements - Ph.D. in a scientific field. Three to five (3+, 5+) years of specialized experience plus a Master’s degree is equivalent to a Ph.D. Five to eight (5+, 8+) years of specialized experience plus a - BA/BS degree is equivalent to a Ph.D. Minimum of nine (9) years of experience in a science related field is required. - Demonstrates expert knowledge working in the research laboratory environment. Computer skills to include MS Office Suite. - Must be a team player who can effectively work with members from cross-functional departments. - Demonstrated knowledge of maintaining accurate and detailed records. - Strong oral and written communication skills. - Familiarity with computer software including word processing, data evaluation, and project timeline management. - This position is for bio-separation scientist. Experience is preferred on capillary experience, chromatographic analysis of protein molecules. Prior industry experience is preferred but not required.   Benefits - 100% Medical, Dental & Vision premium coverage for Employees - Paid Time Off (Including Holidays) - Employee Referral Bonus - 401K Match - Tuition reimbursement and professional development opportunities - Flexible Spending Accounts: - Healthcare (FSA) - Parking Reimbursement Account (PRK) - Dependent Care Assistant Program (DCAP) - Transportation Reimbursement Account (TRN)   The diversity of Axle’s employees is a tremendous asset. We are firmly committed to providing equal opportunity in all aspects of employment and will not tolerate any illegal discrimination or harassment-based age, race, gender, religion, national origin, disability, marital status, covered veteran status, sexual orientation, status with respect to public assistance, and other characteristics protected under state, federal, or local law and to deter those who aid, abet, or induce discrimination or coerce others to discriminate.   Accessibility: If you need an accommodation as part of the employment process please contact: careers@axleinfo.com    Disclaimer: The above description is meant to illustrate the general nature of work and level of effort being performed by individual’s assigned to this position or job description. This is not restricted as a complete list of all skills, responsibilities, duties, and/or assignments required. Individuals may be required to perform duties outside of their position, job description or responsibilities as needed.

Axle is a bioscience and information technology company that offers advancements in translational research, biomedical informatics, and data science applications to research centers and healthcare organizations nationally and abroad. With experts in biomedical science, software engineering, and program management, we focus on developing and applying research tools and techniques to empower decision-making and accelerate research discoveries. We work with some of the top research organizations and facilities in the country including multiple institutes at the National Institutes of Health (NIH). Axle is seeking a Scientist to join our vibrant team at the National Institutes of Health (NIH) supporting the National Center for Advancing Translational Sciences (NCATS) located in Rockville, MD. Benefits We Offer: - 100% Medical, Dental & Vision Coverage for Employees - Paid Time Off and Paid Holidays - 401K match up to 5% - Educational Benefits for Career Growth - Employee Referral Bonus - Flexible Spending Accounts: - Healthcare (FSA) - Parking Reimbursement Account (PRK) - Dependent Care Assistant Program (DCAP) - Transportation Reimbursement Account (TRN) Overall Position Summary and Objectives Under this task order, the contractor will independently provide support services to satisfy the overall operational objectives of the National Center for Advancing Translational Sciences, Therapeutics Development Branch (TDB). The primary objective is to provide services and deliverables through the performance of support services. Deliverables: - Upon request, the contractor shall provide documentation evidence of any and/or all work products, including, but not limited to, the following tasks (Quarterly): - Work on products and documents related to scaling up and synthesizing APIs and intermediates; design and develop scalable synthetic routes; optimize synthetic steps; isolate and identify impurities. - Work on products and documents related to producing research reports; generate reports to support technology transfer to CROs; conduct and write literature reviews; search chemical databases for journal articles, patents and related technologies; publish and present relevant projects. - Work products and documents related to collaboration with the technology transfer office and external patent offices to provide the necessary information for filing patents in selected programs. - Clean Equipment - Weekly - Meet with lab members to present updates - Monthly Work Details: - Provides laboratory experience needed to assist in performing various chemical experiments and procedures. - Perform synthetic route scouting 1 - Perform bulk-synthesis, purification and formulation efforts for advanced testing in animal models. 2 - Perform chemical and biochemical reactions and appropriate analytical analyses. - Perform analytical validation and testing of compositions. - Utilizes and operates various complex laboratory machines and equipment. - Perform general maintenance and upkeep of equipment and instrumentation. - Troubleshoot and provide routine maintenance of the instruments and equipment. - Monitor, troubleshoot and initiate or take corrective action to maintain instrument function and quality. - Identify the cause of common problems and mistakes and make necessary repairs. - Documents and analyzes results, produces detailed summaries and reports. - Write papers and abstracts detailing research efforts and results for publication in peer-reviewed journals. - Maintain up-to-date electronic laboratory notebook detailing all experiments. 3 - Collect and review data; analyze and interpret data and results. - Produce research reports and communicate results. - Search chemical databases for journal articles, patents and related technologies. 5 - Gather, analyze and interpret data; prepare summaries and reports. 4 - Analyzes organic and inorganic compounds to determine chemical and physical properties, composition, structure, relationships between compounds, and reactions. - Formulate chemistry plans for the development of soluble, potent, selective small molecule probes of biological function. - Analyze samples using validated analytical methods for ongoing studies. - Perform the total syntheses of target compounds. - Manage bulk-synthesis, purification and formulation efforts for advanced testing in animal models. - Perform chemical synthesis and optimization of small molecule probes for use in biological research. - Perform organic synthesis of key materials (e.g., reference compounds and precursors for labeling). - Perform organic synthesis in support of the medicinal chemistry program. - Perform solid state analysis of target compounds - Adds heat, light, energy or a catalyst to show changes in composition. - Purify compounds by preparative chromatography from chemists. - Provides laboratory experience needed to perform various complex chemical experiments and procedures. - Perform bulk-synthesis, purification and formulation efforts for advanced testing in animal models. - Perform analytical validation and testing of compositions. - Prepares test solutions, compounds, and reagents and maintains necessary laboratory supplies. - Prepare reagents and maintain an active inventory of all chemicals kept in the laboratory. - Keep an active inventory of all chemicals kept in the laboratory. - Schedules, tracks and reports analyses of experiments and procedures. - Perform analytical validation and testing of compositions and report results. - Maintain computer database for various records. - Independently provides laboratory experience needed to perform various complex chemical experiments and procedures. - Perform bulk-synthesis, purification and formulation efforts for advanced testing in animal models. - Develop new analytical and separation techniques for the solution of scientific questions. - Perform analytical validation and testing of compositions. - Designs and optimizes chemical experiments and procedures. - Develop and document new procedures. - Develop novel chemistry methodologies and technologies that advance the field and make recommendations. - Collaborate with staff to evaluate and/or develop new techniques. - Develop and present plans for novel syntheses and approaches to new compounds. - Develop experimental procedures and research protocols. - Develop and present plans for novel syntheses and approaches to new compounds. - Carry out scale-up of the chemical probes of interest for additional studies. - Trains staff on new experiments and practices, operations and maintenance of instruments and equipment, safety practices, etc. - Maintain and perform training on scientific instrumentation and equipment. - Work with staff on all mandatory training and competency assessments. - Coordinate safety training (e.g., CPR and fire extinguisher use). - Work with facilities manager on evacuation procedures and drills. 1, 2, 3, 4, 5 represents priority rankings, where 1 is highest priority and 5 is lowest priority of those ranked Minimum Education Masters Additional Qualifications: Certifications & Licenses - Good Manufacturing Practice (GMP)  Field of Study - Chemistry  Software - Powerpoint - MS Project - Outlook - Excel - Word  Skills - Microscopy: Confocal, Electron, Multi-Photon, Fluorescence, Super-Resolution - Nuclear Magnetic Resonance - Thin-layer chromatography - X-Ray Crystallography - Manuscript writing - Mass Spectrometry - Spectrophotometry - Thermal analytical technologies - Chromatography technologies (HPLC, UPLC, GC, IC) - Kilo Lab or pilot plant experience Disclaimer:The above description is meant to illustrate the general nature of work and level of effort being performed by individuals assigned to this position or job description. This is not restricted as a complete list of all skills, responsibilities, duties, and/or assignments required. Individuals may be required to perform duties outside of their position, job description or responsibilities as needed. The diversity of Axle’s employees is a tremendous asset. We are firmly committed to providing equal opportunity in all aspects of employment and will not tolerate any illegal discrimination or harassment based on age, race, gender, religion, national origin, disability, marital status, covered veteran status, sexual orientation, status with respect to public assistance, and other characteristics protected under state, federal, or local law and to deter those who aid, abet, or induce discrimination or coerce others to discriminate. Accessibility: If you need an accommodation as part of the employment process please contact: careers@axleinfo.com

Axle Informatics is a bioscience and information technology company that offers advancements in translational research, biomedical informatics, and data science applications to research centers and healthcare organizations nationally and abroad. With experts in biomedical science, software engineering, and program management, we focus on developing and applying research tools and techniques to empower decision-making and accelerate research discoveries. We work with some of the top research organizations and facilities in the country including multiple institutes at the National Institutes of Health (NIH).    Axle is seeking a highly ambitious, adaptable, structured, and detail-oriented Medicinal Chemist to join our vibrant team at the National Institutes of Health (NIH) supporting the National Center for Advancing Translational Sciences (NCATS) located in Rockville, MD.    Overall Position Summary and Objectives We seek an individual to support the work of the Chemical Technologies group at NCATS. This individual will provide services in solving difficult synthetic and medicinal chemistry challenges. The ideal candidate would demonstrate strong and up-to-date knowledge of synthetic organic chemistry methods, particularly as they are used in drug discovery settings for the preparation of both single compounds and small libraries.   Deliverables: - Execute multistep synthesis routes to prepare final target compounds as singletons or small libraries, and on scales ranging from milligram to multigram, as project needs dictate - Weekly Work Details: - Provides laboratory experience needed to assist in performing various chemical experiments and procedures. - Perform chemical and biochemical reactions and appropriate analytical analyses. - Perform multistep organic syntheses to prepare final target compounds - Synthesize and optimize chemical probes for potency and solubility. 3 - Utilizes and operates various complex laboratory machines and equipment. - Operates instruments such as NMR, LCMS and microwave reactor - Documents and analyzes results, produces detailed summaries and reports. - Conduct and write literature reviews for current and future projects. - Maintain up-to-date electronic laboratory notebook detailing all experiments. - Collect and review data; analyze and interpret data and results. - Search chemical databases for journal articles, patents and related technologies. - Analyzes organic and inorganic compounds to determine chemical and physical properties, composition, structure, relationships between compounds, and reactions. - Analyze samples using validated analytical methods for ongoing studies. - Perform the total syntheses of target compounds. 2 - Perform chemical synthesis and optimization of small molecule probes for use in biological research. - Perform organic synthesis in support of the medicinal chemistry program. 1 - Adds heat, light, energy or a catalyst to show changes in composition. - Purify compounds by preparative chromatography from chemists. - Provides laboratory experience needed to perform various complex chemical experiments and procedures. - Synthesize and optimize chemical probes for potency and solubility. - Prepares test solutions, compounds, and reagents and maintains necessary laboratory supplies. - Prepare reagents and maintain an active inventory of all chemicals kept in the laboratory. 5 - Schedules, tracks and reports analyses of experiments and procedures. - Devise synthetic routes to target molecules; produce 10-100 member libraries with acceptable purity and deliver quantities to support biological assays. 4 - Independently provides laboratory experience needed to perform various complex chemical experiments and procedures. - Perform analytical validation and testing of compositions. - Independently design, synthesize and optimize chemical probes for potency and solubility. - Designs and optimizes chemical experiments and procedures. - Develop and present plans for novel syntheses and approaches to new compounds. - Carry out scale-up of the chemical probes of interest for additional studies. - Trains staff on new experiments and practices, operations and maintenance of instruments and equipment, safety practices, etc. - Work with staff to coordinate and assist junior laboratory staff in the design and execution of proper chemical/biochemical protocols. - Designs, optimizes, and troubleshoots chemical experiments and procedures. - Recognize unexpected test discrepancies; identify causes of discrepancies; analyze problems and recommend solutions; devise new methods to more accurately measure analyses. - Troubleshoot and modify existing procedures. - Manages overall maintenance of laboratory. - Participate in laboratory clean-up events and aid laboratory managers in organizing stock-rooms and bench areas. - Maintains, operates and calibrates numerous machines for use in various experiments and procedures. - Operates instruments such as NMR, LCMS and microwave. 1, 2, 3, 4, 5 represents priority rankings, where 1 is highest priority and 5 is lowest priority of those ranked     Minimum Education   Master's   Additional Qualifications:   Certifications & Licenses - B.S., M.S. or Ph.D. in Organic Chemistry - 5 years of experience and B.S. equivalent to a M.S. Field of Study - Chemistry Software - Powerpoint - Excel - Word - Outlook Skills - Nuclear Magnetic Resonance - Thin-layer chromatography - Experience in Organic Synthesis       Benefits   - 100% Medical Dental & Vision Coverage for Employees - Educational Benefits for Career Growth - Paid Time Off (Including Holidays) - Employee Referral Bonus - Profit Sharing - 401K Matching - Flexible Spending Accounts: - Healthcare (FSA) - Parking Reimbursement Account (PRK) - Dependent Care Assistant Program (DCAP) - Transportation Reimbursement Account (TRN)   The diversity of Axle’s employees is a tremendous asset. We are firmly committed to providing equal opportunity in all aspects of employment and will not tolerate any illegal discrimination or harassment based on age, race, gender, religion, national origin, disability, marital status, covered veteran status, sexual orientation, status with respect to public assistance, and other characteristics protected under state, federal, or local law and to deter those who aid, abet, or induce discrimination or coerce others to discriminate.   Accessibility: If you need an accommodation as part of the employment process please contact: careers@axleinfo.com   Disclaimer: The above description is meant to illustrate the general nature of work and level of effort being performed by individual’s assigned to this position or job description. This is not restricted as a complete list of all skills, responsibilities, duties, and/or assignments required. Individuals may be required to perform duties outside of their position, job description or responsibilities as needed.

Axle Informatics is a scientific research and information technology company that offers innovative computer services, informatics, and bioresearch solutions to research centers and healthcare organizations around the globe. With expertise in software engineering, bioinformatics, molecular research, and program management, we focus on developing and applying technological tools and scientific techniques to empower the world of research. We work with some of the top research organizations and facilities in the country including multiple institutes at the National Institutes of Health (NIH). We are looking for a to support projects at the NIH. The company is based in North Bethesda, Maryland but the position is fully remote. We are looking for a skilled and motivated senior software engineer with expertise in algorithm development, distributed systems, software design, and scientific workflow automation. You will be involved with developing scientific workflow software supporting our open-source molecular modeling, image analysis, and scientific data platform. The software will facilitate high throughput screening, drug discovery, and other molecular modeling efforts across the NIH. You will work with synthetic chemists, assay biologists, and other domain experts to translate their needs into requirements for the platform. You will participate in software design and documentation; stay current with technical literature; and stay informed about new approaches and technologies. You will also be involved in performing detailed code review and mentoring junior developers. You should have expert knowledge in developing Python and Javascript applications using best practices such as type annotations, unit testing, etc. Experience with Typescript and REST apis is required. Ideally you will have some experience dealing with distributed systems and issues such as synchronization & atomicity, network timeouts & polling loops, schedulers, retry mechanisms, message brokers, etc.

We are seeking a Program Support Specialist to join the team at Axle Informatics.     Axle Informatics is a bioscience and information technology company that offers advancements in translational research, biomedical informatics, and data science applications to research centers and healthcare organizations around the globe. With experts in biomedical science, software engineering, and program management, we focus on developing and applying research tools and techniques to empower decision-making and accelerate research discoveries. We work with some of the top research organizations and facilities in the country including multiple institutes at the National Institutes of Health (NIH).     Responsibilities   - Interfacing with employees and program leadership on a regular basis. - Providing program support and assisting in managing Axle staff within the NIH. - Coordinating employee travel and training requests in accordance with NIH and Axle policies and procedures and reviewing, certifying expense reports. - Coordinating annual performance reviews. - Conducting new employee orientations, reviewing, and approving timesheets.  - Act as a liaison between the Program and Corporate with respect to Human Resources/Benefits Inquiries. - Establish and maintain cooperative working relationships with a diverse group of staff members, stakeholders, and customers to support successful performance across operations and projects.  - Develop and maintain both program and technical documentation and Standard Operating Procedures. - Work with project teams to ensure compliance with contract requirements.     Qualifications   - Previous experience interfacing with employees and government contracting experience within NIH a plus.  - Ability to be client facing and deal with staff of all levels with utmost professionalism  - Must be extremely detail oriented  - Should have the ability to anticipate business unit needs, take initiative, and follow through on assignments.  - Very strong interpersonal skills required with excellent oral, written, and verbal communication skills. Ability to work and multi-task in a fast-paced environment.  - Proficiency with MS Office required.    Benefits     - 100% Medical, Dental & Vision premium coverage for Employees    - Paid Time Off (Including Holidays)   - Employee Referral Bonus    - 401K Match   - Tuition reimbursement and professional development opportunities   - Flexible Spending Accounts:  - Healthcare (FSA)  - Parking Reimbursement Account (PRK)  - Dependent Care Assistant Program (DCAP)  - Transportation Reimbursement Account (TRN)    The diversity of Axle’s employees is a tremendous asset. We are firmly committed to providing equal opportunity in all aspects of employment and will not tolerate any illegal discrimination or harassment based age, race, gender, religion, national origin, disability, marital status, covered veteran status, sexual orientation, status with respect to public assistance, and other characteristics protected under state, federal, or local law and to deter those who aid, abet, or induce discrimination or coerce others to discriminate.   Accessibility: If you need an accommodation as part of the employment process please contact:     Email: careers@axleinfo.com     Disclaimer: The above description is meant to illustrate the general nature of work and level of effort being performed by individual’s assigned to this position or job description. This is not restricted as a complete list of all skills, responsibilities, duties, and/or assignments required. Individuals may be required to perform duties outside of their position, job description or responsibilities as needed.